Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling.

Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Research Abstract Details 

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Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Abstract Text:

Eukaryotic 2-Cys peroxiredoxins (2-Cys Prxs) not only act as antioxidants, but also appear to regulate hydrogen peroxide-mediated signal transduction. We show that bacterial 2-Cys Prxs are much less sensitive to oxidative inactivation than are eukaryotic 2-Cys Prxs. By identifying two sequence motifs unique to the sensitive 2-Cys Prxs and comparing the crystal structure of a bacterial 2-Cys Prx at 2.2 angstrom resolution with other Prx structures, we define the structural origins of sensitivity. We suggest this adaptation allows 2-Cys Prxs to act as floodgates, keeping resting levels of hydrogen peroxide low, while permitting higher levels during signal transduction.

Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Publishing Authors By Initials

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MEDLINE DATE:

Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Science (New York, N.Y.)

VOLUME: 300

Page Numbers: 650-3

Journal Abbreviation: Science

ISSN: 1095-9203

DAY: 25

MONTH: Apr

YEAR: 2003

Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 404511

Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Keywords Mesh Terms:

KEYWORDS: Yeasts

MESH TERMS: enzymology

Chemical & Substance for Abstract: Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Information

Substance Name: Peroxiredoxins

Registry Number: EC 1.11.1.15

Grant and Affiliation Information for Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling.

AFFILIATION: Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97333, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM050389-10

ACRONYM: GM

MEDLINETA: Science

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ACCESSION NUMBER: 1N8J

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