Permeation of tecnazene through human skin in vitro as assessed by HS-SPME and GC-MS.

Permeation of tecnazene through human skin in vitro as assessed by HS-SPME and GC-MS. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Permeation of tecnazene through human skin in vitro as assessed by HS-SPME and GC-MS. Abstract Text:

Permeation of tecnazene into and through human cadaver skin in vitro was assessed using a CC-MS method employing HS-SPME for receptor solution analyses. Two doses of tecnazene dissolved in acetone, corresponding to 103 and 864 microg/cm2 of tecnazene, were applied to skin mounted on Franz diffusion cells and placed in a fume hood. Cells were either occluded with aluminum foil or left unoccluded. Total absorption of tecnazene (dermis + receptor fluid) after 48 h was 2.2-6.1% of the applied dose for the unoccluded treatments and 22-33% for the occluded treatments. Potentially absorbed dose including all tecnazene that may have eventually permeated the skin ranged from 10% unoccluded to 42-53% occluded. Accumulation in the receptor solutions was satisfactorily described by a working diffusion model after upward adjustment of the partition coefficient for tecnazene in all skin layers by a factor of 5-16 versus a priori values. However, residual amounts of tecnazene in both the epidermis and dermis were higher than those estimated from the model, suggesting the existence of tissue binding not accounted for in the calculation. The results indicate that the diffusion model as presently calibrated may significantly underestimate both systemic absorption and skin concentrations of highly lipophilic compounds, as predicted from data generated from in vitro skin permeation assays. Model predictions could be improved by better accounting for partitioning into the epidermis and dermis.

Permeation of tecnazene through human skin in vitro as assessed by HS-SPME and GC-MS. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Permeation of tecnazene through human skin in vitro as assessed by HS-SPME and GC-MS. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Environmental science & technology

VOLUME: 42

Page Numbers: 6587-92

Journal Abbreviation: Environ. Sci. Technol.

ISSN: 0013-936X

DAY: 1

MONTH: Sep

YEAR: 2008

Permeation of tecnazene through human skin in vitro as assessed by HS-SPME and GC-MS. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 213155

Permeation of tecnazene through human skin in vitro as assessed by HS-SPME and GC-MS. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Permeation of tecnazene through human skin in vitro as assessed by HS-SPME and GC-MS. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Permeation of tecnazene through human skin in vitro as assessed by HS-SPME and GC-MS.

AFFILIATION: James L. Winkle College of Pharmacy, University of Cincinnati Academic Health Center, P.O. Box 670004, Cincinnati, Ohio 45267-0004, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Environ Sci Technol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Permeation of tecnazene through human skin in vitro as assessed by HS-SPME and GC-MS Related Publications

• A critical role for central vasopressin in regulation of fever during bacterial infection.
• A geometrical model of dermal capillary clearance.
• Central vasopressin V1-blockade prevents salicylate but not acetaminophen antipyresis.
• Central vasopressin V1-receptors mediate indomethacin-induced antipyresis in rats.
• Centrally acting vasopressin contributes to endotoxin tolerance.
• Effect of hydration on the permeation of ketoconazole through human nail plate in vitro.
• Equilibrium water sorption characteristics of the human nail.
• Glucose partition coefficient and diffusivity in the lower skin layers.
• Partitioning, diffusivity and clearance of skin permeants in mammalian dermis.
• Permeation of tecnazene through human skin in vitro as assessed by HS-SPME and GC-MS.
• Session 22. Habitability of super-earths.
• Thermodynamics of water interaction with human stratum corneum I: measurement by isothermal calorimetry.
• Two-stage kinetic analysis of fragrance evaporation and absorption from skin.
• Unusual computed tomographic presentation of cerebral toxoplasmosis.
• Water diffusivity in human nail plate.