Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1.

Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1. Abstract Text:

Tulin O Price,Willis K Samson,Michael L Niehoff,William A Banks,Tulin O Price,Willis K Samson,Michael L Niehoff,William A Banks,

Nesfatin-1 has recently been identified as a hypothalamic and brain stem peptide that regulates feeding behavior. Here, we determined the ability of nesfatin-1 to cross the blood-brain barrier (BBB) of mice. We used multiple-regression analysis to determine that radioactively labeled nesfatin-1 injected intravenously entered the brain. The entry rate (K(i)) of (131)I-nesfatin-1 from blood-to-brain was 0.20+/-0.02mul/gmin. This modest rate of entry was not inhibited by the administration of nonradioactive nesfatin-1, suggesting that BBB transport of nesfatin-1 into the brain is by a nonsaturable mechanism. High performance liquid chromatography (HPLC) and acid precipitation showed that most of the injected radiolabeled nesfatin-1 reached the brain as intact peptide, and capillary depletion with vascular washout revealed that 67% of (131)I-nesfatin-1 crossed the BBB to reach the brain parenchyma. Efflux of labeled nesfatin-1 from brain back into blood was by way of bulk flow. These findings demonstrate that nesfatin-1 crosses the BBB in both the blood-to-brain and brain-to-blood directions by nonsaturable mechanisms.

Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1. Publishing Authors By Initials

TO Price,WK Samson,ML Niehoff,WA Banks,TO Price,WK Samson,ML Niehoff,WA Banks,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Peptides

VOLUME: 28

Page Numbers: 2372-81

Journal Abbreviation: Peptides

ISSN: 0196-9781

DAY: 18

MONTH: 10

YEAR: 2007

Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8008690

Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1.

AFFILIATION: Geriatric Research, Education, and Clinical Center (GRECC), Veteran Affairs Medical Center, St. Louis and Division of Geriatrics, Department of Internal Medicine, St. Louis University School of Medicine, 915 N. Grand Blvd., St. Louis, MO 63106, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Peptides

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1 Related Publications

• 3-Amino-4-hydroxybenzenearsonic acid; oxophenarsine hydrochloride; decomposition rate.
• 3-Amino-4-hydroxybenzenearsonous acid; oxophenarsine hydrochloride; decomposition products.
• A dynamic model for induced reactivation of latent virus.
• A prospective, randomized trial of clear liquids versus low-fat solid diet as the initial meal in mild acute pancreatitis.
• A rational approach to the design of highly effective chiral stationary phases for the liquid chromatographic separation of enantiomers.
• Algal growth response and survival in a range of light and temperature conditions: implications for non-steady-state conditions in waste stabilisation ponds.
• Apparatus for filtration under reduced pressure.
• Associations between employees' work schedules and the vocational consequences of workplace injuries.
• At the cross-roads; the development of our health services.
• Brain-immune communication pathways.
• Candidate loci reveal genetic differentiation between temporally divergent migratory runs of Chinook salmon (Oncorhynchus tshawytscha).
• Deep-water kelp refugia as potential hotspots of tropical marine diversity and productivity.
• Duplicated Clock genes with unique polyglutamine domains provide evidence for nonhomologous recombination in Chinook salmon (Oncorhynchus tshawytscha).
• Effects of participation in consumer-operated service programs on both personal and organizationally mediated empowerment: Results of multisite study.
• Effects of radiograph projection parameter uncertainty on TKA kinematics from model-image registration.
• Incorporating ecologically relevant measures of pesticide effect for estimating the compatibility of pesticides and biocontrol agents.
• Intraoperative assessment of bone cuts to guide surgical technique during total knee arthroplasty.
• Isolation of a Bacillus anthracis-like organism from a periapical abscess.
• Modified therapeutic community treatment for offenders with MICA disorders: substance use outcomes.
• Muscarinic blockade weakens interaction of gamma with theta rhythms in mouse hippocampus.
• Notes on Perlidae.
• PATHOLOGICAL FRACTURES; A CONSIDERATION WITH METACHONDROMATOSIS AND DIFFERENTIAL DIAGNOSES: Osteochondromatosis and Gauchers Disease.
• Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1.
• Proteomic profiling identifies afamin as a potential biomarker for ovarian cancer.
• Removal of Prussian blue from contaminated soil in the rhizosphere of cyanogenic plants.
• Restoration of acutely thrombosed arterio-venous fistulae by rTPA and percutaneous angioplasty.
• Substituted chlorodiamino-s-triazines.
• Surgical treatment of sterility.
• The impact of early trauma and abuse on residential substance abuse treatment outcomes for women.
• Using mathematical modeling and control to develop structured treatment interruption strategies for HIV infection.