Permanent alterations of spinal cord reflexes following nerve lesion in newborn rats.

Permanent alterations of spinal cord reflexes following nerve lesion in newborn rats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Permanent alterations of spinal cord reflexes following nerve lesion in newborn rats. Abstract Text:

R Vejsada,J Palecek,P ,

Sciatic nerve lesion in newborn rats is known to cause degeneration of a large number of axotomized motoneurones and spinal ganglion cells. Some of the surviving motoneurones exhibit abnormal firing properties and the projection pattern of central terminals of sensory neurones is altered. We report here on long-term changes in spinal cord reflexes in adult rats following neonatal nerve crush. In acutely spinalized and anaesthetized adult rats 4-6 months old in which the sciatic nerve had been crushed on one side at birth, the tibial nerve, common peroneal nerve or sural nerve were stimulated on the reinnervated and control side and reflex responses were recorded from the L5 ventral spinal roots. Ventral root responses (VRRs) to tibial and peroneal nerve stimulation on the side of the nerve lesion were significantly smaller in amplitude representing only about 15% of the mean amplitude of VRRs on the control side. The calculated central delay of the first, presumably monosynaptic component of the VRR potential was 1.6 ms on the control side while the earliest VRR wave on the side of the nerve lesion appeared after a mean central latency of 4.0 ms that seems too long to be of monosynaptic origin. These results suggest that neonatal sciatic nerve injury markedly alters the physiological properties and synaptic connectivity in spinal cord neurones and causes a marked depression of spinal cord responses to peripheral nerve stimulation.

Permanent alterations of spinal cord reflexes following nerve lesion in newborn rats. Publishing Authors By Initials

R Vejsada,J Palecek,P ,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

PUBMED ID PMID:

MEDLINE DATE:

Permanent alterations of spinal cord reflexes following nerve lesion in newborn rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Physiological research / Academia Scientiarum Bohe

VOLUME: 48

Page Numbers: 483-9

Journal Abbreviation: Physiol Res

ISSN: 0862-8408

DAY: 2

MONTH: 04

YEAR: 1999

Permanent alterations of spinal cord reflexes following nerve lesion in newborn rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9112413

Permanent alterations of spinal cord reflexes following nerve lesion in newborn rats. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: physiology

Chemical & Substance for Abstract: Permanent alterations of spinal cord reflexes following nerve lesion in newborn rats. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Permanent alterations of spinal cord reflexes following nerve lesion in newborn rats.

AFFILIATION: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.

Country: CZECH REPUBLIC

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Physiol Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Permanent alterations of spinal cord reflexes following nerve lesion in newborn rats Related Publications

• Function and structure of atypical muscle spindles after neonatal nerve crush in rats.
• Neuromuscular research in Czechoslovakia.
• Permanent alterations of spinal cord reflexes following nerve lesion in newborn rats.