Peritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markers.

Peritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markers. Research Abstract Details 

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Peritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markers. Abstract Text:

Adhemar Longatto-Filho,Céline Pinheiro,Luísa Ferreira,Cristovam Scapulatempo,Venancio A F Alves,Fátima Baltazar,Fernando Schmitt,

To evaluate whether lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) are useful markers of worse outcome in colorectal carcinoma and if LVD and LVI correlate to the classical clinical-pathological parameters, we analysed 120 cases of colorectal carcinomas selected from the files of Division of Pathology, Hospital das Clinicas, São Paulo University, Brazil. Assessment of LVD and LVI was performed by immunohistochemical detection of lymphatic vessels, using the monoclonal antibody D2-40. Higher LVD was found in the intratumoural area, when comparing with normal and peritumoural areas (p < 0.001). However, peritumoural LVD, but not intratumoural, correlated with both colonic-wall-invasion depth (p = 0.037) and liver metastasis (p = 0.012). Remarkably, LVI was found associated with local invasion (p = 0.016), nodal metastasis (p = 0.022) and hepatic metastasis (p < 0.001). Peritumoural LVD and LVI are directly related to histopathological variables indicative of poor outcome such as lymph-node status and liver metastasis.

Peritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markers. Publishing Authors By Initials

A Longatto-Filho,C Pinheiro,L Ferreira,C Scapulatempo,VA Alves,F Baltazar,F Schmitt,

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Peritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markers. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Virchows Archiv : an international journal of path

VOLUME: 452

Page Numbers: 133-8

Journal Abbreviation: Virchows Arch.

ISSN: 0945-6317

DAY: 18

MONTH: 12

YEAR: 2007

Peritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markers. Information

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LANGUAGE: eng

NlmUniqueID: 9423843

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AFFILIATION: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057, Braga, Portugal, longatto@ecsaude.uminho.pt.

Country: Germany

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MEDLINETA: Virchows Arch

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