Peritoneal lavage with doxycycline in acute diffuse peritonitis.

Peritoneal lavage with doxycycline in acute diffuse peritonitis. Research Abstract Details 

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Peritoneal lavage with doxycycline in acute diffuse peritonitis. Abstract Text:

Peritoneal lavage with ten hourly repeated instillation-drainages of one litre lavage fluid containing 50 mg doxycycline (Vibramycin Pfizer) was carried out on six patients suffering from diffuse peritonitis due to perforated appendicitis. Bacteriological specimens were obtained both from the perforation in the appendix and the peritoneal fluid at operation and the doxycycline concentrations in blood and lavage fluid were determined at intervals up to 72 hours postoperatively. All the patients recovered, but the lavage was considered a failure in one case as a small abscess and multiple adhesions were found at reoperation 1 1/2 months later. Bacteriological swabs from the perforated appendix and the peritoneal fluid usually contained the same bacteriological species, and as a rule several species were isolated. Doxycycline compared favourably with ampicillin as regards bacterial sensitivity, but the difference was too slight to be of practical importance. Doxycycline was absorbed very rapidly from the peritoneal cavitiy, and due to its slow excretion a cumulation occurred. In this small series doxycycline did not appear to give any real advantage over ampicillin, but it may be considered the drug of choice in patients with penicillin allergy, and in those who fail to respond to ampicillin.

Peritoneal lavage with doxycycline in acute diffuse peritonitis. Publishing Authors By Initials

For similar digestive system diseases: peritoneal diseases: peritonitis research abstracts see: digestive system diseases: peritoneal diseases: peritonitis research

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Peritoneal lavage with doxycycline in acute diffuse peritonitis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annales chirurgiae et gynaecologiae. Supplementum

VOLUME: 65

Page Numbers: 22-6

Journal Abbreviation:

ISSN: 0355-9874

DAY: 26

MONTH: 02

YEAR: 1976

Peritoneal lavage with doxycycline in acute diffuse peritonitis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7702959

Peritoneal lavage with doxycycline in acute diffuse peritonitis. Keywords Mesh Terms:

KEYWORDS: Peritonitis

MESH TERMS: microbiology

Chemical & Substance for Abstract: Peritoneal lavage with doxycycline in acute diffuse peritonitis. Information

Substance Name: Ampicillin

Registry Number: 69-53-4

Grant and Affiliation Information for Peritoneal lavage with doxycycline in acute diffuse peritonitis.

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Country: FINLAND

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MEDLINETA: Ann Chir Gynaecol Suppl

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