Peripheral nerve regeneration through alginate gel: analysis of early outgrowth and late increase in diameter of regenerating axons.

Peripheral nerve regeneration through alginate gel: analysis of early outgrowth and late increase in diameter of regenerating axons. Research Abstract Details 

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Peripheral nerve regeneration through alginate gel: analysis of early outgrowth and late increase in diameter of regenerating axons. Abstract Text:

T Hashimoto,Y Suzuki,M Kitada,K Kataoka,S Wu,K Suzuki,K Endo,Y Nishimura,C Ide,

Our previous study revealed that alginate gel cross-linked with covalent bonds promoted peripheral nerve regeneration in the cat and rat. The present study analyzed nerve regeneration through alginate gel in the early stages within 2 weeks and the late stages up to 21 months after implantation. Four days after surgery, regenerating axons grew without Schwann cell investment through the partially degraded alginate gel, being in direct contact with the alginate without a basal lamina covering. Numerous mast cells infiltrated into the alginate. One to 2 weeks after surgery, regenerating axons were surrounded by common Schwann cells to form small bundles, with some axons at the periphery being partly in direct contact with alginate. At the distal stump, numerous Schwann cells had migrated into the alginate 8-14 days after surgery. They had no basal laminae. The diameter of regenerated myelinated fibers was small (approximately 1 micro m) at 8 weeks, but increased in diameter, having a distribution pattern similar to that of normal nerve 21 months after surgery. Much better nerve regeneration was found in alginate gel-, than collagen sponge-, and fibrin glue-implanted distal stump 12 months after surgery. These results indicate that alginate gel has good biocompatibility for regenerating axon outgrowth and Schwann cell migration, and that regenerated fibers can have a diameter as thick as that of normal fibers in the long term. Alginate gel is a promising material for use as an implant for peripheral nerve regeneration.

Peripheral nerve regeneration through alginate gel: analysis of early outgrowth and late increase in diameter of regenerating axons. Publishing Authors By Initials

T Hashimoto,Y Suzuki,M Kitada,K Kataoka,S Wu,K Suzuki,K Endo,Y Nishimura,C Ide,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Peripheral nerve regeneration through alginate gel: analysis of early outgrowth and late increase in diameter of regenerating axons. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 146

Page Numbers: 356-68

Journal Abbreviation:

ISSN: 0014-4819

DAY: 22

MONTH: 08

YEAR: 2002

Peripheral nerve regeneration through alginate gel: analysis of early outgrowth and late increase in diameter of regenerating axons. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Peripheral nerve regeneration through alginate gel: analysis of early outgrowth and late increase in diameter of regenerating axons. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Peripheral nerve regeneration through alginate gel: analysis of early outgrowth and late increase in diameter of regenerating axons. Information

Substance Name: alginic acid

Registry Number: 9005-32-7

Grant and Affiliation Information for Peripheral nerve regeneration through alginate gel: analysis of early outgrowth and late increase in diameter of regenerating axons.

AFFILIATION: Department of Anatomy and Neurobiology and Cell Biology, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku,, Japan.

Country: Germany

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MEDLINETA: Exp Brain Res

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