Peripheral deletion of mature alloreactive B cells induced by costimulation blockade.

Peripheral deletion of mature alloreactive B cells induced by costimulation blockade. Research Abstract Details 

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Peripheral deletion of mature alloreactive B cells induced by costimulation blockade. Abstract Text:

Yijin Li,Lianli Ma,Jikun Shen,Anita S Chong,

Alloreactive B cells can contribute to graft rejection. Anti-CD154 treatment together with donor-specific transfusion (DST) results in the long-term survival of MHC-mismatched mouse heart grafts and inhibition of alloantibody production. To characterize the mechanism of B cell tolerance induced by the anti-CD154 and DST, we used 3-83Igi mice, on BALB/c (H-2K(d)) background, that express a B cell receptor that reacts with MHC class I antigens H-2K(b). Transplanting C57BL/6 (H-2K(b)) hearts into 3-83Igi mice, followed by tolerance induction, resulted in the peripheral deletion of mature but not immature 3-83 B cells. The sustained deletion of mature alloreactive B cells required the presence of the allograft and can be explained by the absence of T cell help.

Peripheral deletion of mature alloreactive B cells induced by costimulation blockade. Publishing Authors By Initials

Y Li,L Ma,J Shen,AS Chong,

For similar surgical procedures, operative: transplantation: transplantation, homologous research abstracts see: surgical procedures, operative: transplantation: transplantation, homologous research

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Peripheral deletion of mature alloreactive B cells induced by costimulation blockade. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 12093-8

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 3

MONTH: 07

YEAR: 2007

Peripheral deletion of mature alloreactive B cells induced by costimulation blockade. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Peripheral deletion of mature alloreactive B cells induced by costimulation blockade. Keywords Mesh Terms:

KEYWORDS: Transplantation, Homologous

MESH TERMS: cytology

Chemical & Substance for Abstract: Peripheral deletion of mature alloreactive B cells induced by costimulation blockade. Information

Substance Name: CD40 Ligand

Registry Number: 147205-72-9

Grant and Affiliation Information for Peripheral deletion of mature alloreactive B cells induced by costimulation blockade.

AFFILIATION: Department of Surgery, Section of Transplantation, University of Chicago, Chicago, IL 60637, USA. yijinli@uchicago.edu

Country: United States

AGENCY: United States NIAID

GRANT: 2R56AI043631-07A2

ACRONYM: AI

MEDLINETA: Proc Natl Acad Sci U S A

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