Peripheral Blood Neutrophils as Independent Immunologic Predictor of Response and Long-Term Survival upon Immunotherapy in Metastatic Renal-Cell Carcinoma.

Peripheral Blood Neutrophils as Independent Immunologic Predictor of Response and Long-Term Survival upon Immunotherapy in Metastatic Renal-Cell Carcinoma. Research Abstract Details 

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Peripheral Blood Neutrophils as Independent Immunologic Predictor of Response and Long-Term Survival upon Immunotherapy in Metastatic Renal-Cell Carcinoma. Abstract Text:

Jens Atzpodien,Martina Reitz,

The aim of this study was to evaluate the prognostic impact of pretreatment neutrophils, previously rendered statistically independent, on the response and on long-term survival of metastatic renal carcinoma patients treated with outpatient subcutaneous (s.c.) interleukin-2 (IL-2) and s.c. interferon (IFN)-alpha. We assessed a total of 495 patients receiving s.c. IL-2/s.c. IFN-alpha-based therapy. While 417 patients with neutrophil counts <6500 cells/muL at baseline achieved 30% objective responses and a median survival of 22 months, 78 patients with pretreatment neutrophil counts >=6500 cells/muL had 18% objective responses and a median survival of 9 months (p = 0.0000). In conclusion, pretreatment periphal blood neutrophils <6500/muL constitute an immunologic predictor of tumor response and long-term survival in metastatic renal-cell carcinoma patients treated with s.c. IL-2 and s.c. IFN-alpha-based regimens.

Peripheral Blood Neutrophils as Independent Immunologic Predictor of Response and Long-Term Survival upon Immunotherapy in Metastatic Renal-Cell Carcinoma. Publishing Authors By Initials

J Atzpodien,M Reitz,

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Peripheral Blood Neutrophils as Independent Immunologic Predictor of Response and Long-Term Survival upon Immunotherapy in Metastatic Renal-Cell Carcinoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer biotherapy & radiopharmaceuticals

VOLUME: 23

Page Numbers: 129-34

Journal Abbreviation: Cancer Biother. Radiopharm.

ISSN: 1084-9785

DAY: 26

MONTH: Feb

YEAR: 2008

Peripheral Blood Neutrophils as Independent Immunologic Predictor of Response and Long-Term Survival upon Immunotherapy in Metastatic Renal-Cell Carcinoma. Information

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LANGUAGE: eng

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AFFILIATION: Fachklinik Hornheide an der Westfälischen Wilhelms-Universität Münster, Münster, Germany, Europäisches Institut für Tumor Immunologie und Prävention, Bad Honnef, Germany.

Country: United States

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MEDLINETA: Cancer Biother Radiopharm

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