Peripheral blood CD34+ cell mobilization in 42 patients with severe autoimmune disease.

Peripheral blood CD34+ cell mobilization in 42 patients with severe autoimmune disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Peripheral blood CD34+ cell mobilization in 42 patients with severe autoimmune disease. Abstract Text:

Wei Zhang,Dao-Bin Zhou,Yan Zhao,Jun-Ling Zhuang,Xiao-Mei Leng,Shu-Jie Wang,Li Jiao,Fu-Lin Tang,Jie-Ping Zhang,Xuan Wang,Ti Shen,

OBJECTIVE: To evaluate the feasibility and safety of peripheral CD34+ cell mobilization in patients with severe autoimmune disease. METHODS: Forty-two patients underwent a total of 46 mobilizations by the regimen of cyclophosphamide 2-3 g/m2+ recombinant human granulocyte colony stimulating factor (rhG-CSF) 5 microg x kg(-1) x d(-1). The positive selection of CD34+ cell was performed through the CliniMACS. RESULTS: In 8.1 +/- 2. 3 days after administration of cyclophosphamide, the peripheral white blood cell and mononuclear cell (MNC) decreased to the lowest level. In 3.7 +/- 1.6 days after injection of rhG-CSF, the peripheral absolute MNC and CD34+ cell counts were 0.95 x 10(9)/L and 0.035 x 10(9)/L, respectively. After 2.4 +/- 0.6 times of leukapheresis, there gained 4.46 x 10(8)/kg of MNC and 5.26 x 10(6)/kg of CD34+, respectively. After mobilization, the underlying diseases were ameliorated more or less. In systemic lupus erythematosus (SLE) patients, SLE Disease Activity Index (SLEDAI) decreased from a median of 17 to 3 (P < 0.01). In rheumatic arthritis patients, an American College of Rheumatology criteria for 20% (ACR20) response was achieved in all five patients. Totally, 17.4% of patients whose absolute neutrophil count < 0.5 x 10(9)/L suffered infection, and 31.0% of patients had bone pain after the injection of rhG-CSF. Two patients suffered severe complications, one with acute renal failure and recovered by hemodialysis, the other died of thrombotic thrombocytopenic purpura. Failed mobilization occurred in three patients. CONCLUSIONS: Sufficient CD34+ cells can be mobilized by low dose of cyclophosphamide and rhG-CSF. CD34+ cell mobilization for treatment of severe autoimmune disease not only is appropriate in both effectiveness and safety but ameliorates disease also.

Peripheral blood CD34+ cell mobilization in 42 patients with severe autoimmune disease. Publishing Authors By Initials

W Zhang,DB Zhou,Y Zhao,JL Zhuang,XM Leng,SJ Wang,L Jiao,FL Tang,JP Zhang,X Wang,T Shen,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Peripheral blood CD34+ cell mobilization in 42 patients with severe autoimmune disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Chinese medical sciences journal = Chung-kuo i hsü

VOLUME: 22

Page Numbers: 108-12

Journal Abbreviation: Chin. Med. Sci. J.

ISSN: 1001-9294

DAY: 3

MONTH: Jun

YEAR: 2007

Peripheral blood CD34+ cell mobilization in 42 patients with severe autoimmune disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9112559

Peripheral blood CD34+ cell mobilization in 42 patients with severe autoimmune disease. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Peripheral blood CD34+ cell mobilization in 42 patients with severe autoimmune disease. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Peripheral blood CD34+ cell mobilization in 42 patients with severe autoimmune disease.

AFFILIATION: Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Chin Med Sci J

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Peripheral blood CD34+ cell mobilization in 42 patients with severe autoimmune disease Related Publications

• Comment on "Direct measurement of the 'Giant' adiabatic temperature change in Gd5Si2Ge2".
• Comparison of IL-6-induced STAT1 activation in different responsive cells.
• [Advanced life support in prehospital emergency treatment of trauma]
• [Application of long distance-PCR to hemophilia A carrier detection and prenatal diagnosis]
• [Cell cycle analysis and P53 gene mutation detection of fibroblasts derived from the surrounding skin of keloids]
• [Clinical investigation of application of lung biopsy in the diagnosis of diffuse pulmonary interstitial disease]
• [Continuous target of China's manned space project and research direction of space medico-engineering]
• [Coronary artery bypass grafting after acute myocardial infarction]
• [Development of an anti-rTNF-alpha chimeric antibody]
• [Effect of staining method and sintering temperature on the color of porcelain-fused-to-metal restorations]
• [Effects of microgravity on human cognitive function in space flight]
• [Epidemic investigation on 3 to 6 years children's bruxism in Shanghai.]
• [Epidemiology and drug resistance of the pathogenic microbes in the complicated infection of hematological malignancies]
• [European Society of cardiology guideline (III): percutaneous coronary interventions Emergency department]
• [Expectation of the study of weightlessness physiology in the 21st century]
• [Expression of adhesion molecules on CD34(+) hematopoietic precursor cells from normal human bone marrow, cord blood and mobilized blood]
• [Expression of monoclonal nonspecific suppressor factor beta in E. coli, preparation of its antibodies and its tissue orientation in the mouse endometrium]
• [Fiberoptic ductoscopy for patients with intraductal papillary lesions]
• [Non-extraction approach using RPE to correct Angle Class I malocclusion with moderate crowding: A cephalometric study]
• [Observation on the effects of urapidil on hemodynamics in heart dysfunction dogs by thoracic electrical bioimpedance]
• [Relationship between the human zygote type and embryo implantation potential]
• [Relationship of vitamin D receptor polymorphism with breast cancer]
• [Science face upto to fact of undiscovered, frustration and challenge from severe acute respiratory syndrome]
• [Site-specific mutagenesis of murine anti-human TNF-alpha Fab gene and its expression in E.coli]
• [Study on the mechanism of the effects of recombinant rat tumor necrosis factor alpha on the degradation of rat skeletal muscle proteins]
• [Study on the relationship between sulfonylurea receptor 1 gene polymorphism and type 2 diabetes mellitus]
• [Superiority of traditional Chinese medicine on gene regulation]
• [The epidemiological study of severe acute respiratory syndrome]
• [Transfer and expression of rh-SCF gene in human hematopoietic stem/progenitor cells]
• [Treatment of AMI with ST segment hoist]