Peripheral and central catecholaminergic neurons in genetic and experimental hypertension in rats.

Peripheral and central catecholaminergic neurons in genetic and experimental hypertension in rats. Research Abstract Details 

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Peripheral and central catecholaminergic neurons in genetic and experimental hypertension in rats. Abstract Text:

H Grobecker,J M Saavedra,M F Roizen,V Weise,I J Kopin,J Axelrod,

1. Activity of peripheral and central catecholaminergic neurons was studied in spontaneously hypertensive rats (SHR) and deoxycorticosterone (DOCA)-salt hypertensive rats. 2. In young SHR (4 weeks) the plasma values of bpth noradrenaline and dopamine-beta-hydroxylase activity were increased compared with those of normotensive rats of the Wistar/Kyoto strain. Total catecholamines (mostly adrenaline) were not significantly different. 3. In the adrenal glands of 2-weeks-old and 4-weeks-old SHR activities of tyrosine hydroxylase, dopamine-beta-hydroxylase, phenylethanolamine-N-methyl transferase were decreased, compared to Wistar/Kyoto rats. 4. The adrenaline-forming enzyme was elevated in the A1 and A2 regions of the brain stem of 4-weeks-old SHR and in the A1 region of adult DOCA-salt hypertensive rats. 5. In the adrenal glands of adult DOCA-salt hypertensive rats tyrosine hydroxylase activity was increased. 6. These results implicate peripheral noradrenaline-containing neurons and central adrenaline-containing neurons in the development of genetic and experimental hypertension in rats.

Peripheral and central catecholaminergic neurons in genetic and experimental hypertension in rats. Publishing Authors By Initials

H Grobecker,JM Saavedra,MF Roizen,V Weise,IJ Kopin,J Axelrod,

For similar enzymes and coenzymes: enzymes: oxidoreductases: oxygenases: mixed function oxygenases: tyrosine 3-monooxygenase research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases: oxygenases: mixed function oxygenases: tyrosine 3-monooxygenase research

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Peripheral and central catecholaminergic neurons in genetic and experimental hypertension in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical science and molecular medicine. Supplemen

VOLUME: 3

Page Numbers: 377s-380s

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ISSN: 0144-4107

DAY: 12

MONTH: Dec

YEAR: 1976

Peripheral and central catecholaminergic neurons in genetic and experimental hypertension in rats. Information

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LANGUAGE: eng

NlmUniqueID: 7907311

Peripheral and central catecholaminergic neurons in genetic and experimental hypertension in rats. Keywords Mesh Terms:

KEYWORDS: Tyrosine 3-Monooxygenase

MESH TERMS: metabolism

Chemical & Substance for Abstract: Peripheral and central catecholaminergic neurons in genetic and experimental hypertension in rats. Information

Substance Name: Methyltransferases

Registry Number: EC 2.1.1.-

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Country: ENGLAND

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MEDLINETA: Clin Sci Mol Med Suppl

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