Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair.

Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Research Abstract Details 

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Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Abstract Text:

Bernhard ,Federica del Monte,Roger J Hajjar,Yuh-Shin Chang,Djamel Lebeche,Shima Arab,Mark T Keating,

Adult mammalian hearts respond to injury with scar formation and not with cardiomyocyte proliferation, the cellular basis of regeneration. Although cardiogenic progenitor cells may maintain myocardial turnover, they do not give rise to a robust regenerative response. Here we show that extracellular periostin induced reentry of differentiated mammalian cardiomyocytes into the cell cycle. Periostin stimulated mononucleated cardiomyocytes to go through the full mitotic cell cycle. Periostin activated alphaV, beta1, beta3 and beta5 integrins located in the cardiomyocyte cell membrane. Activation of phosphatidylinositol-3-OH kinase was required for periostin-induced reentry of cardiomyocytes into the cell cycle and was sufficient for cell-cycle reentry in the absence of periostin. After myocardial infarction, periostin-induced cardiomyocyte cell-cycle reentry and mitosis were associated with improved ventricular remodeling and myocardial function, reduced fibrosis and infarct size, and increased angiogenesis. Thus, periostin and the pathway that it regulates may provide a target for innovative strategies to treat heart failure.

Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Publishing Authors By Initials

B ,F del Monte,RJ Hajjar,YS Chang,D Lebeche,S Arab,MT Keating,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration research

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Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature medicine

VOLUME: 13

Page Numbers: 962-9

Journal Abbreviation: Nat. Med.

ISSN: 1078-8956

DAY: 15

MONTH: 07

YEAR: 2007

Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9502015

Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Keywords Mesh Terms:

KEYWORDS: Regeneration

MESH TERMS: drug effects

Chemical & Substance for Abstract: Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Information

Substance Name: 1-Phosphatidylinositol 3-Kinase

Registry Number: EC 2.7.1.137

Grant and Affiliation Information for Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair.

AFFILIATION: Department of Cardiology, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA. bernhard.kuhn@cardio.chboston.org

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL078691

ACRONYM: HL

MEDLINETA: Nat Med

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