Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH.

Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH. Abstract Text:

Takakazu Kawamata,Akio Inui,Hiroshi Hosoda,Kenji Kangawa,Tomokatsu Hori,

OBJECTIVE: Ghrelin is a novel gastric peptide known to stimulate GH secretion, but the relationship between ghrelin and the GH-insulin-like growth factor (IGF)-1 axis in GH excess or deficiency is poorly understood. This study investigated dysregulation of ghrelin secretion in acromegaly and its short-term postoperative recovery. METHODS: A prospective study was conducted on eight patients who underwent complete transsphenoidal resection of GH-producing pituitary adenomas (acromegaly group) and 22 for endocrinologically nonfunctioning pituitary tumours (control group). Active and total plasma ghrelin levels were measured serially before and after surgery. RESULTS: Preoperative active and total plasma ghrelin concentrations (mean +/- SD; fmol/ml) were significantly reduced in acromegalic patients when compared with those in the controls (9.6 +/- 4.3 and 157.4 +/- 65.6 vs. 21.8 +/- 13.0 and 267.1 +/- 111.4; P = 0.023 and P = 0.021, respectively). Both levels were still significantly suppressed on postoperative Day 7 in the acromegaly group when compared with those in the control group (11.7 +/- 4.3 and 197.8 +/- 68.9 vs. 22.5 +/- 12.6 and 302.7 +/- 100.0; P = 0.038 and P = 0.018, respectively). The ratios of active to total ghrelin were not significantly different between the two groups before and after operation. In acromegalic patients, active and total ghrelin levels remained significantly suppressed even after normalization of serum GH levels. CONCLUSIONS: The putative negative feedback mechanism of GH on ghrelin secretion may in part account for the low ghrelin levels observed in acromegalic patients, and the mechanism may persist even after normalization of serum GH.

Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH. Publishing Authors By Initials

T Kawamata,A Inui,H Hosoda,K Kangawa,T Hori,

For similar surgical procedures, operative: postoperative period research abstracts see: surgical procedures, operative: postoperative period research

PUBMED ID PMID:

MEDLINE DATE:

Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical endocrinology

VOLUME: 67

Page Numbers: 140-4

Journal Abbreviation: Clin. Endocrinol. (Oxf)

ISSN: 0300-0664

DAY: 27

MONTH: 04

YEAR: 2007

Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 346653

Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH. Keywords Mesh Terms:

KEYWORDS: Postoperative Period

MESH TERMS: surgery

Chemical & Substance for Abstract: Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH. Information

Substance Name: Growth Hormone

Registry Number: 9002-72-6

Grant and Affiliation Information for Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH.

AFFILIATION: Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan. tkawamata@nij.twmu.ac.jp

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Clin Endocrinol (Oxf)

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH Related Publications

• A dibenzoylmethane derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum stress.
• A smart video magnifier controlled by the visibility signal of a low vision user.
• Adrenodoxin-cytochrome P450scc interaction as revealed by EPR spectroscopy: comparison with the putidaredoxin-cytochrome P450cam system.
• Compact synchrotron light source of the HSRC.
• Determination of nonylphenol ethoxylates and octylphenol ethoxylates in environmental samples using 13C-labeled surrogate compounds.
• Differences in substrate selectivities of the SPOUT superfamily of methyltransferases.
• Drug-resistance gene expression and progression of astrocytic tumors.
• Effect of combined humanPTH(1-34) and calcitonin treatment in ovariectomized rats.
• Effect of intracoronary thrombectomy on 30-day mortality in patients with acute myocardial infarction.
• Effect of molecular chirality and side chain bulkiness on angiogenesis of haloacetylcarbamoyl-2-nitroimidazole compounds.
• Effect on Outcome of an Increase of Serum Cardiac Troponin T in Patients With Healing or Healed ST-Elevation Myocardial Infarction.
• Enhancement of synaptic transmission and nociceptive behaviour in HPC-1/syntaxin 1A knockout mice following peripheral nerve injury.
• Hetero subunit interaction and RNA recognition of yeast tRNA (m7G46) methyltransferase synthesized in a wheat germ cell-free translation system.
• Hydroxyl radical probing of tRNA (Gm18) methyltransferase [TrmH]-AdoMet-artificial tRNA ternary complex.
• Influence of the signal-to-noise ratio on the accuracy of IOLMaster measurements.
• Isolation of diacylglycerol-2-aminoethylphosphonate from Tetrahymena pyriformis.
• Long-term oral administration of dipyridamole improves both cardiac and physical status in patients with mild to moderate chronic heart failure: a prospective open-randomized study.
• Modified permanent middle cerebral artery occlusion rat model aiming to reduce variability in infarct size.
• Motor evoked potential mapping and monitoring by direct brainstem stimulation. Technical note.
• Nicardipine prolonged-release implants for preventing cerebral vasospasm after subarachnoid hemorrhage: effect and outcome in the first 100 patients.
• Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH.
• Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia.
• Right-handed snakes: convergent evolution of asymmetry for functional specialization.
• Selective peripheral denervation of the levator scapulae muscle for laterocollic cervical dystonia.
• Sequence motif-specific assignment of two [2Fe-2S] clusters in rat xanthine oxidoreductase studied by site-directed mutagenesis.
• The carboxyl-terminus directs TAF(I)48 to the nucleus and nucleolus and associates with multiple nuclear import receptors.
• Vertebrate collagenase: direct extraction from animal skin and human synovial membrane.
• Visual emotional context modulates brain potentials elicited by unattended tones.
• [Current status and problems in approval of new anticancer drugs in Japan]
• [Jervell and Lange-Nielsen syndrome]