PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator.

PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Research Abstract Details 

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PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Abstract Text:

Steven A Brown,Juergen Ripperger,Sebastian Kadener,Fabienne Fleury-Olela,Francis Vilbois,Michael Rosbash,Ueli Schibler,

The clock proteins PERIOD1 (PER1) and PERIOD2 (PER2) play essential roles in a negative transcriptional feedback loop that generates circadian rhythms in mammalian cells. We identified two PER1-associated factors, NONO and WDR5, that modulate PER activity. The reduction of NONO expression by RNA interference (RNAi) attenuated circadian rhythms in mammalian cells, and fruit flies carrying a hypomorphic allele were nearly arrhythmic. WDR5, a subunit of histone methyltransferase complexes, augmented PER-mediated transcriptional repression, and its reduction by RNAi diminished circadian histone methylations at the promoter of a clock gene.

PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Publishing Authors By Initials

SA Brown,J Ripperger,S Kadener,F Fleury-Olela,F Vilbois,M Rosbash,U Schibler,

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PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Science (New York, N.Y.)

VOLUME: 308

Page Numbers: 693-6

Journal Abbreviation: Science

ISSN: 1095-9203

DAY: 29

MONTH: Apr

YEAR: 2005

PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Information

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LANGUAGE: eng

NlmUniqueID: 404511

PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Keywords Mesh Terms:

KEYWORDS: Transfection

MESH TERMS: metabolism

Chemical & Substance for Abstract: PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Information

Substance Name: Wdr5 protein, mouse

Registry Number: 0

Grant and Affiliation Information for PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator.

AFFILIATION: Department of Molecular Biology and National Centres of Competence in Research (NCCR) Frontiers in Genetics, Sciences III, University of Geneva, 30 Quai Ernest Ansermet, CH-1211 Geneva-4, Switzerland. steven.brown@molbio.unige.ch

Country: United States

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MEDLINETA: Science

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