Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy.

Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy. Research Abstract Details 

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Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy. Abstract Text:

Brian M Casey,Jodi S Dashe,Catherine Y Spong,Donald D McIntire,Kenneth J Leveno,Gary F Cunningham,

OBJECTIVE: To establish pregnancy-specific free thyroxine thresholds and to assess perinatal effects associated with isolated maternal hypothyroxinemia identified in the first half of pregnancy. METHODS: Stored serum samples from 17,298 women who previously underwent thyroid-stimulating hormone (TSH) screening in the first half of pregnancy were analyzed for free thyroxine (T(4)) concentrations and thyroid peroxidase antibodies. Women with a free T(4) below 0.86 ng/dL but a normal-range TSH were identified to have isolated maternal hypothyroxinemia. Pregnancy outcomes in these women were compared to those with a normal TSH and free T(4). Thyroid peroxidase antibody status and the relationship between TSH and free T(4) were analyzed for these women and women with subclinical hypothyroidism. RESULTS: Isolated maternal hypothyroxinemia was identified in 233 women (1.3%). There were not any excessive adverse pregnancy outcomes in these women. Positive thyroid peroxidase antibody assays (greater than 50 international units/mL) were similar in normal women (4%) and those with isolated hypothyroxinemia (5%) but were greater in women with subclinical hypothyroidism (31%, P<.001). There was a negative correlation between TSH and free T(4) in normal women (r(s)=-0.19, P<.001) and those with subclinical hypothyroidism (r(s)=-0.11, P=.007). The correlation in women with isolated hypothyroxinemia was not significant. CONCLUSION: Isolated maternal hypothyroxinemia has no adverse effects on perinatal outcome. Moreover, unlike subclinical hypothyroidism, there was a low prevalence of thyroid peroxidase antibodies and no correlation between TSH and free T(4) levels in women with hypothyroxinemia, leading us to question its biological significance.

Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy. Publishing Authors By Initials

BM Casey,JS Dashe,CY Spong,DD McIntire,KJ Leveno,GF Cunningham,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: thyroid hormones: thyroxine research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: thyroid hormones: thyroxine research

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Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Obstetrics and gynecology

VOLUME: 109

Page Numbers: 1129-35

Journal Abbreviation:

ISSN: 0029-7844

DAY: 3

MONTH: May

YEAR: 2007

Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 401101

Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy. Keywords Mesh Terms:

KEYWORDS: Thyroxine

MESH TERMS: blood

Chemical & Substance for Abstract: Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy. Information

Substance Name: Iodide Peroxidase

Registry Number: EC 1.11.1.8

Grant and Affiliation Information for Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy.

AFFILIATION: Department of Obstetrics and Gynecology, the University of Texas Southwestern Medical Center, Dallas, Texas 75390-9032, USA. brian.casey@utsouthwestern.edu

Country: United States

AGENCY: United States NICHD

GRANT: HD-04-023

ACRONYM: HD

MEDLINETA: Obstet Gynecol

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