Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy paediatric population.

Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy paediatric population. Research Abstract Details 

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Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy paediatric population. Abstract Text:

Kendra A Young,Lezlie A Parrish,Gary O Zerbe,Marian Rewers,Kevin D Deane,V Michael Holers,Jill M Norris,

OBJECTIVE: To examine perinatal and childhood risk factors for the presence of rheumatoid factor in healthy children. METHODS: The Diabetes Autoimmunity Study in the Young (DAISY) is a longitudinal study of children at increased risk of type 1 diabetes, based on possession of human leucocyte antigen (HLA)-DR4 and DR3 alleles or a family history of diabetes. 651 children who participated in DAISY, with an average age of 6.4 (range 1-15) years, were tested for the presence of rheumatoid factor in their most recent serum sample. 23 children were positive for rheumatoid factor. Exposure data were collected prospectively by interview. HLA-DR4 alleles were identified using polymerase chain reaction-based Class II genotyping. RESULTS: While exploring risk factors for rheumatoid factor positivity in a multivariate model, several important interaction terms involving HLA-DR4 status suggested the need to evaluate risk factors in HLA-DR4-positive and HLA-DR4-negative children separately. In HLA-DR4-negative children, rheumatoid factor-positive infants were less likely to have been breast fed for >3 months (odds ratio (OR) 0.18; 95% confidence interval (CI) 0.04 to 0.99), more likely to have been exposed to non-parental tobacco smoke (OR 5.38; 95% CI 0.93 to 31.27) and more likely to be a race/ethnicity other than non-Hispanic white (OR 6.94; 95% CI 1.10 to 43.88) compared with rheumatoid factor-negative children, after adjusting for age, sex and maternal education. In HLA-DR4-positive children, there were no significantly associated risk factors for rheumatoid factor positivity. CONCLUSIONS: Risk factors for rheumatoid factor positivity in children vary by HLA-DR4 genotype. In HLA-DR4-negative children, breast feeding may decrease the risk, and environmental tobacco smoke may increase the risk, of autoimmunity.

Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy paediatric population. Publishing Authors By Initials

KA Young,LA Parrish,GO Zerbe,M Rewers,KD Deane,V Michael Holers,JM Norris,

For similar complex mixtures: particulate matter: smoke: tobacco smoke pollution research abstracts see: complex mixtures: particulate matter: smoke: tobacco smoke pollution research

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Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy paediatric population. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Annals of the rheumatic diseases

VOLUME: 66

Page Numbers: 179-83

Journal Abbreviation: Ann. Rheum. Dis.

ISSN: 0003-4967

DAY: 3

MONTH: Feb

YEAR: 2007

Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy paediatric population. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372355

Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy paediatric population. Keywords Mesh Terms:

KEYWORDS: Tobacco Smoke Pollution

MESH TERMS: analysis

Chemical & Substance for Abstract: Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy paediatric population. Information

Substance Name: Rheumatoid Factor

Registry Number: 9009-79-4

Grant and Affiliation Information for Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy paediatric population.

AFFILIATION: Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Box B119, Denver, CO 80262, USA.

Country: England

AGENCY: United States NIDDK

GRANT: R01 DK49654

ACRONYM: DK

MEDLINETA: Ann Rheum Dis

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