Perimuscular connective tissue contains more and larger lymphatic vessels than the shallower layers in human gallbladders.

Perimuscular connective tissue contains more and larger lymphatic vessels than the shallower layers in human gallbladders. Research Abstract Details 

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Perimuscular connective tissue contains more and larger lymphatic vessels than the shallower layers in human gallbladders. Abstract Text:

Masayuki Nagahashi,Yoshio Shirai,Toshifumi Wakai,Jun Sakata,Yoichi Ajioka,Katsuyoshi Hatakeyama,Masayuki Nagahashi,Yoshio Shirai,Toshifumi Wakai,Jun Sakata,Yoichi Ajioka,Katsuyoshi Hatakeyama,

AIM: To clarify whether perimuscular connective tissue contains more lymphatic vessels than the shallower layers in human gallbladders. METHODS: Lymphatic vessels were stained immunohistochemically with monoclonal antibody D2-40, which is a specific marker of lymphatic endothelium, in representative sections of 12 normal human gallbladders obtained at the time of resection for colorectal carcinoma liver metastases. In individual gallbladder specimens, nine high-power (x 200) fields with the highest lymphatic vessel density (LVD), termed "hot spots", were identified for each layer (mucosa, muscle layer, and perimuscular connective tissue). In individual hot spots, the LVD and relative lymphatic vessel area (LVA) were measured microscopically using a computer-aided image analysis system. The mean LVD and LVA values for the nine hot spots in each layer were used for statistical analyses. RESULTS: In the mucosa, muscle layer, and perimuscular connective tissue, the LVD was 16.1 +/- 9.2, 35.4 +/- 15.7, and 65.5 +/- 12.2, respectively, and the LVA was 0.4 +/- 0.4, 2.1 +/- 1.1, and 9.4 +/- 2.6, respectively. Thus, both the LVD and LVA differed significantly (P < 0.001 and P < 0.001, respectively; Kruskal-Wallis test) among the individual layers of the wall of the gallbladder, with the highest LVD and LVA values in the perimuscular connective tissue. Most (98 of 108) of the hot spots within the perimuscular connective tissue were located within 500 mum of the lower border of the muscle layer. CONCLUSION: The perimuscular connective tissue contains more and larger lymphatic vessels than the shallower layers in the human gallbladder. This observation partly explains why the incidence of lymph node metastasis is high in T2 (tumor invading the perimuscular connective tissue) or more advanced gallbladder carcinoma.

Perimuscular connective tissue contains more and larger lymphatic vessels than the shallower layers in human gallbladders. Publishing Authors By Initials

M Nagahashi,Y Shirai,T Wakai,J Sakata,Y Ajioka,K Hatakeyama,M Nagahashi,Y Shirai,T Wakai,J Sakata,Y Ajioka,K Hatakeyama,

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Perimuscular connective tissue contains more and larger lymphatic vessels than the shallower layers in human gallbladders. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: World journal of gastroenterology : WJG

VOLUME: 13

Page Numbers: 4480-3

Journal Abbreviation: World J. Gastroenterol.

ISSN: 1007-9327

DAY: 7

MONTH: Sep

YEAR: 2007

Perimuscular connective tissue contains more and larger lymphatic vessels than the shallower layers in human gallbladders. Information

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LANGUAGE: eng

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AFFILIATION: Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-Dori, Niigata City, Japan.

Country: China

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MEDLINETA: World J Gastroenterol

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