Periadolescent nicotine exposure reduces cocaine reward in adult mice.

Periadolescent nicotine exposure reduces cocaine reward in adult mice. Research Abstract Details 

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Periadolescent nicotine exposure reduces cocaine reward in adult mice. Abstract Text:

Fully mature mice exposed to low levels of nicotine during periadolescence exhibited reductions in the rewarding and subjective effects of cocaine. These results provide converging validity that periadolescent nicotine exposure can permanently decrease a subject's sensitivity to the reinforcing effects of cocaine. These changes were noted long after exposure, suggesting that nicotine may have altered neural systems mediating drug reward. Since reductions in the rewarding value of abused drugs are associated with increased self-administration, periadolescent nicotine exposure might increase the risk for substance abuse problems. The study thus provides biological support that nicotine might serve a "gateway" function for substance abuse.

Periadolescent nicotine exposure reduces cocaine reward in adult mice. Publishing Authors By Initials

For similar pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight gain research abstracts see: pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight gain research

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MEDLINE DATE:

Periadolescent nicotine exposure reduces cocaine reward in adult mice. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of addictive diseases

VOLUME: 18

Page Numbers: 27-39

Journal Abbreviation:

ISSN: 1055-0887

DAY: 12

MONTH: 05

YEAR: 1999

Periadolescent nicotine exposure reduces cocaine reward in adult mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107051

Periadolescent nicotine exposure reduces cocaine reward in adult mice. Keywords Mesh Terms:

KEYWORDS: Weight Gain

MESH TERMS: drug effects

Chemical & Substance for Abstract: Periadolescent nicotine exposure reduces cocaine reward in adult mice. Information

Substance Name: Nicotine

Registry Number: 54-11-5

Grant and Affiliation Information for Periadolescent nicotine exposure reduces cocaine reward in adult mice.

AFFILIATION: Bridgewater College, VA 22812, USA.

Country: UNITED STATES

AGENCY: United States NIDA

GRANT: DA08034

ACRONYM: DA

MEDLINETA: J Addict Dis

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