Peri-stent reference segment plaque burden is associated with disease progression in saphenous vein grafts (a serial intravascular ultrasound assessment).

Peri-stent reference segment plaque burden is associated with disease progression in saphenous vein grafts (a serial intravascular ultrasound assessment). Research Abstract Details 

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Peri-stent reference segment plaque burden is associated with disease progression in saphenous vein grafts (a serial intravascular ultrasound assessment). Abstract Text:

Young Joon Hong,Gary S Mintz,Sang Wook Kim,Teruo Okabe,Li Lu,Anh B Bui,Augusto D Pichard,Lowell F Satler,Ron Waksman,Kenneth M Kent,William O Suddath,Neil J Weissman,Young Joon Hong,Gary S Mintz,Sang Wook Kim,Teruo Okabe,Li Lu,Anh B Bui,Augusto D Pichard,Lowell F Satler,Ron Waksman,Kenneth M Kent,William O Suddath,Neil J Weissman,

We are aware of no studies of peri-stent disease progression or luminal compromise in saphenous vein graft (SVG) lesions. We used serial intravascular ultrasound (IVUS) to assess disease progression in peri-stent saphenous vein bypass graft reference segments. We studied 37 peri-stent SVG reference segments in 21 patients; 16 were proximal and 21 were distal to the stent. The same anatomic image slice was analyzed after the intervention and at follow-up; this site was 3.68 +/- 2.22 mm from the stent edge. Graft age was 10.1 +/- 5.4 years, and mean follow-up duration was 13 months (range 3 to 61). Overall, change in SVG area, change in lumen area, and change in plaque burden correlated with postintervention plaque burden (r = 0.448, p = 0.005; r = -0.584, p <0.001; and r = 0.507, p = 0.001, respectively). For the proximal edge, change in lumen area correlated with change in plaque area (r = -0.951, p <0.001), but not with change in SVG area (r = -0.337, p = 0.201). For the distal edge, change in lumen area correlated more strongly with change in plaque area (r = -0.982, p <0.001) than with change in SVG area (r = -0.624, p = 0.003). When peri-stent reference segments were divided into 2 groups according to postintervention plaque burden (>50% [n = 20] vs <50% [n = 17]), there was a greater decrease in lumen area (-1.12 +/- 0.81 vs -0.33 +/- 0.26 mm(2), p <0.001) and greater increases in SVG area (0.26 +/- 0.29 vs 0.09 +/- 0.09 mm(2), p = 0.027), plaque area (1.37 +/- 0.96 vs 0.42 +/- 0.30 mm(2), p <0.001), and plaque burden (8.2 +/- 5.6% vs. 2.8 +/- 1.6%, p <0.001) in segments with a plaque burden >50%. In conclusion, peri-stent reference segment SVG disease progression and lumen loss were more significant in segments with a greater postintervention plaque burden after implantation of a bare metal stent or drug-eluting stent.

Peri-stent reference segment plaque burden is associated with disease progression in saphenous vein grafts (a serial intravascular ultrasound assessment). Publishing Authors By Initials

YJ Hong,GS Mintz,SW Kim,T Okabe,L Lu,AB Bui,AD Pichard,LF Satler,R Waksman,KM Kent,WO Suddath,NJ Weissman,YJ Hong,GS Mintz,SW Kim,T Okabe,L Lu,AB Bui,AD Pichard,LF Satler,R Waksman,KM Kent,WO Suddath,NJ Weissman,

For similar diagnosis: diagnostic techniques and procedures: diagnostic imaging: ultrasonography: ultrasonography, interventional research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic imaging: ultrasonography: ultrasonography, interventional research

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Peri-stent reference segment plaque burden is associated with disease progression in saphenous vein grafts (a serial intravascular ultrasound assessment). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The American journal of cardiology

VOLUME: 100

Page Numbers: 1233-8

Journal Abbreviation: Am. J. Cardiol.

ISSN: 0002-9149

DAY: 18

MONTH: 07

YEAR: 2007

Peri-stent reference segment plaque burden is associated with disease progression in saphenous vein grafts (a serial intravascular ultrasound assessment). Information

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LANGUAGE: eng

NlmUniqueID: 207277

Peri-stent reference segment plaque burden is associated with disease progression in saphenous vein grafts (a serial intravascular ultrasound assessment). Keywords Mesh Terms:

KEYWORDS: Ultrasonography, Interventional

MESH TERMS: transplantation

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Grant and Affiliation Information for Peri-stent reference segment plaque burden is associated with disease progression in saphenous vein grafts (a serial intravascular ultrasound assessment).

AFFILIATION: Cardiovascular Research Institute/Medstar Research Institute, Washington Hospital Center, Washington, DC, USA.

Country: United States

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MEDLINETA: Am J Cardiol

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