Performance of a new separator system for routine autologous hematopoietic progenitor cell collection in small children.

Performance of a new separator system for routine autologous hematopoietic progenitor cell collection in small children. Research Abstract Details 

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Performance of a new separator system for routine autologous hematopoietic progenitor cell collection in small children. Abstract Text:

Volker Witt,Elisabeth ,Robert Ritter,Marianne ,Christine Peters,Ruth Ladenstein,Helmut Gadner,Gerhard Fritsch,Volker Witt,Elisabeth Beiglböck,Robert Ritter,Marianne Würth,Christine Peters,Ruth Ladenstein,Helmut Gadner,Gerhard Fritsch,

The AMICUStrade mark system was recently introduced for peripheral blood stem cell (PBSC) aphereses in adults. We conducted a single center field evaluation to obtain data about the performance of this system in children with a body weight (bw) < 25 kg. Results of blood priming procedures were compared to historical data obtained with the Fenwal CS3000+ (CS 3000). From August, 2001 to February, 2007, 47/178 (26%) PBSC aphereses procedures were performed in our institution with the AMICUStrade mark system in 35 small patients (median bw 13.9 kg; range 6.7-24; age 2.78 years; range 0.97-7.06). The patients suffered from various malignant primary diseases or recurrences. We primed the system with packed RBC in case of >30% dilution of the RBC volume (n = 31) or with saline (n = 16). Compared to the CS3000, the AMICUStrade mark revealed comparable collection efficiencies (CE) for CD34(+) cells (median 67%, range 26-120), lymphocytes (75%, 25-138), monocytes (54%, 23-173), and granulocytes (10%, 1.5-36), MNC (57% 24-125), but a significantly higher erythrocyte and granulocyte, and a lower platelet CE. There was a significant negative correlation between total leukocyte count and CE for MNC (r = -0.566; P < 0.001) and CD34(+) cells (r = -0.517; P < 0.001). There was no significant statistical or clinical difference between the CE in blood-primed procedures and saline-primed procedures. With the AMICUStrade mark we saw statistically less citrate reactions compared to the CS 3000. We conclude that the AMICUStrade mark system is safe and efficient to harvest PBSC on a routine basis in pediatric patients, even in children

Performance of a new separator system for routine autologous hematopoietic progenitor cell collection in small children. Publishing Authors By Initials

V Witt,E ,R Ritter,M ,C Peters,R Ladenstein,H Gadner,G Fritsch,V Witt,E Beiglböck,R Ritter,M Würth,C Peters,R Ladenstein,H Gadner,G Fritsch,

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Performance of a new separator system for routine autologous hematopoietic progenitor cell collection in small children. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical apheresis

VOLUME: 22

Page Numbers: 306-13

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ISSN: 0733-2459

DAY: 8

MONTH: 01

YEAR: 2007

Performance of a new separator system for routine autologous hematopoietic progenitor cell collection in small children. Information

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LANGUAGE: eng

NlmUniqueID: 8216305

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Grant and Affiliation Information for Performance of a new separator system for routine autologous hematopoietic progenitor cell collection in small children.

AFFILIATION: St. Anna Kinderspital, Vienna, Austria.

Country: United States

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MEDLINETA: J Clin Apher

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