Performance measurement of the microPET focus 120 scanner.

Performance measurement of the microPET focus 120 scanner. Research Abstract Details 

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Performance measurement of the microPET focus 120 scanner. Abstract Text:

Jin Su Kim,Jae Sung Lee,Ki Chun Im,Su Jin Kim,Seog-Young Kim,Dong Soo Lee,Dae Hyuk Moon,

The microPET Focus 120 scanner is a third-generation animal PET scanner dedicated to rodent imaging. Here, we report the results of scanner performance testing. METHODS: A (68)Ge point source was used to measure energy resolution, which was determined for each crystal and averaged. Spatial resolution was measured using a (22)Na point source with a nominal size of 0.25 mm at the system center and various off-center positions. Absolute sensitivity without attenuation was determined by extrapolating the data measured using an (18)F line source and multiple layers of absorbers. Scatter fraction and counting rate performance were measured using 2 different cylindric phantoms simulating rat and mouse bodies. Sensitivity, scatter fraction, and noise equivalent counting rate (NECR) experiments were repeated under 4 different conditions (energy window, 250 approximately 750 keV or 350 approximately 650 keV; coincidence window, 6 or 10 ns). A performance phantom with hot-rod inserts of various sizes was scanned, and several animal studies were also performed. RESULTS: Energy resolution at a 511-keV photopeak was 18.3% on average. Radial, tangential, and axial resolution of images reconstructed with the Fourier rebinning (FORE) and filtered backprojection (FBP) algorithms were 1.18 (radial), 1.13 (tangential), and 1.45 mm full width at half maximum (FWHM) (axial) at center and 2.35 (radial), 1.66 (tangential), and 2.00 mm FWHM (axial) at a radial offset of 2 cm. Absolute sensitivities at transaxial and axial centers were 7.0% (250 approximately 750 keV, 10 ns), 6.7% (250 approximately 750 keV, 6 ns), 4.0% (350 approximately 650 keV, 10 ns), and 3.8% (350 approximately 650 keV, 6 ns). Scatter fractions were 15.9% (mouse phantom) and 35.0% (rat phantom) for 250 approximately 750 keV and 6 ns. Peak NECR was 869 kcps at 3,242 kBq/mL (mouse phantom) and 228 kcps at 290 kBq/mL (rat phantom) at 250 approximately 750 keV and 6 ns. Hot-rod inserts of 1.6-mm diameter were clearly identified, and animal studies illustrated the feasibility of this system for studies of whole rodents and mid-sized animal brains. CONCLUSION: The results of this independent field test showed the improved physical characteristics of the F120 scanner over the previous microPET series systems. This system will be useful for imaging studies on small rodents and brains of larger animals.

Performance measurement of the microPET focus 120 scanner. Publishing Authors By Initials

JS Kim,JS Lee,KC Im,SJ Kim,SY Kim,DS Lee,DH Moon,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

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Performance measurement of the microPET focus 120 scanner. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of nuclear medicine : official publication

VOLUME: 48

Page Numbers: 1527-35

Journal Abbreviation: J. Nucl. Med.

ISSN: 0161-5505

DAY: 17

MONTH: 08

YEAR: 2007

Performance measurement of the microPET focus 120 scanner. Information

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LANGUAGE: eng

NlmUniqueID: 217410

Performance measurement of the microPET focus 120 scanner. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: instrumentation

Chemical & Substance for Abstract: Performance measurement of the microPET focus 120 scanner. Information

Substance Name: Germanium

Registry Number: 7440-56-4

Grant and Affiliation Information for Performance measurement of the microPET focus 120 scanner.

AFFILIATION: Department of Nuclear Medicine, Seoul National University College of Medicine, 28 Yungun-Dong, Chongno-Gu, Seoul 110-744, Korea.

Country: United States

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MEDLINETA: J Nucl Med

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