Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart.

Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart. Abstract Text:

Chandan K Sen,Savita Khanna,Sashwati Roy,

Focal coronary artery blockage followed by further reperfusion injury is commonly involved in myocardial infarction. The injured heart has some inherent reparative responses. Although such natural healing mechanisms seem to be inefficient, a clear understanding of the underlying principles of myocardial healing holds the key to successful therapy. Under normoxic conditions, pO(2) ranges from 90 to <3 Torr in mammalian organs with the heart at approximately 35 Torr (5%) and arterial blood at approximately 100 Torr. Thus, "normoxia" for cells is an adjustable variable. In response to chronic moderate hypoxia, cells lower their normoxia set-point such that reoxygenation-dependent relative elevation of pO(2) (+DeltapO(2)) results in perceived hyperoxia. Perceived hyperoxia induces differentiation of cardiac fibroblasts to myofibroblasts in the peri-infarct region and represents a significant factor supporting myocardial healing. The oxygen-sensitive signaling pathways involved have been characterized and point towards a central role of p21, TGFbeta and p38MAPK. That low oxygen ambience serves as a cue to trigger angiogenesis is a well-accepted notion. Studies related to perceived hyperoxia establish that the sensing of oxygen environment is not limited to hypoxia. It demonstrates that in addition to being a trigger for injury as is widely recognized, reoxygenation insult has a built-in component of tissue remodeling in the peri-infarct region induced by perceived hyperoxia. Understanding of the underlying mechanisms of this and other myocardial healing responses should prove to be instrumental in developing productive therapeutic approaches to mend the infarcted heart.

Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart. Publishing Authors By Initials

CK Sen,S Khanna,S Roy,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: ventricular function: ventricular remodeling research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: ventricular function: ventricular remodeling research

PUBMED ID PMID:

MEDLINE DATE:

Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart. Journal Published:

PUBLICATION TYPE: Review

Journal: Cardiovascular research

VOLUME: 71

Page Numbers: 280-8

Journal Abbreviation: Cardiovasc. Res.

ISSN: 0008-6363

DAY: 17

MONTH: 02

YEAR: 2006

Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart. Information

Number of References: 113

LANGUAGE: eng

NlmUniqueID: 77427

Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart. Keywords Mesh Terms:

KEYWORDS: Ventricular Remodeling

MESH TERMS: physiology

Chemical & Substance for Abstract: Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart.

AFFILIATION: Laboratory of Molecular Medicine, 512 Davis Heart and Lung Research Institute, Department of Surgery, The Ohio State University Medical Center, 473 W. 12th Avenue, Columbus, 43210, USA. chandan.sen@osumc.edu

Country: Netherlands

AGENCY: United States PHS

GRANT: R01 073087

ACRONYM:

MEDLINETA: Cardiovasc Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart Related Publications

• A novel range based QSAR study of human neuropeptide Y (NPY) Y5 receptor inhibitors.
• Assembly of feline calicivirus-like particle and its immunogenicity.
• Calotropis procera latex extract affords protection against inflammation and oxidative stress in Freund's complete adjuvant-induced monoarthritis in rats.
• Community eye health care for leprosy patients in west bengal, India.
• Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery.
• Development of primordial follicles in the hamster: role of estradiol-17beta.
• Effector proteins translocated by Legionella pneumophila: strength in numbers.
• Emotional distress in women presenting for breast imaging.
• Enhancing antitumor immunity: combining IL-12 with TGFbeta1 antagonism.
• Evaluation of the clinical decisions made for 2-year-olds referred for speech and language therapy: a follow-up study.
• Explosive Force Production and Fractionated Reaction Time in Elderly Low and High Active Women: 974: June 2 10:45 AM - 11:00 AM.
• Explosive force and fractionated reaction time in elderly low- and high-active women.
• Expression of G protein-coupled receptor 30 in the hamster ovary: differential regulation by gonadotropins and steroid hormones.
• Glossal angiomyoma: Imaging findings and endovascular treatment.
• Glycemic control in critically ill patients effect of delay in insulin administration.
• Harlequin fetus.
• Magnesium, essential for base excision repair enzymes, inhibits substrate binding of N-methylpurine-DNA glycosylase.
• Molecular mechanism of insulin resistance.
• Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression.
• Oxidative DNA damage repair in mammalian cells: a new perspective.
• Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart.
• Profiles and correlates of aggressive behaviour among adults with intellectual disabilities.
• Six-year incidence of proteinuria in type 1 diabetic African Americans.
• Surface plasmon resonance as a time-resolved probe of structural changes in molecular films: considerations for correlating resonance shifts with adsorbate layer parameters.
• Survey of clinical engineering in developing countries and model for technology acquisition and diffusion.
• Technical aspects of online hemodiafiltration.
• Tocotrienols: the emerging face of natural vitamin E.
• Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine.
• Where people die: a multilevel approach to understanding influences on site of death in America.
• miRNA: licensed to kill the messenger.