Peptidoglycan recognition protein LF: a negative regulator of Drosophila immunity.

Peptidoglycan recognition protein LF: a negative regulator of Drosophila immunity. Research Abstract Details 

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Peptidoglycan recognition protein LF: a negative regulator of Drosophila immunity. Abstract Text:

Carina Persson,Sandra Oldenvi, Steiner,

Peptidoglycan recognition proteins (PGRPs) play important roles in the innate immune defence. Each PGRP detects a distinct subset of peptidoglycans and initiate immune signalling or enzymatic degradation of peptidoglycans. Here we characterize one of the 13 Drosophila PGRPs, PGRP-LF. PGRP-LF is membrane bound and has its two PGRP domains, z and w, localized outside the cell. Our data demonstrate that the z-and w-domain differ in their affinities to peptidoglycan. The z-domain has affinity to several groups of peptidoglycans while the w-domain only recognizes peptidoglycan from Escherichia coli. In addition, we observed that overexpression of PGRP-LF in Drosophila melanogaster Schneider 2 cells (S2 cells) promotes aggregation of cells. Furthermore, following immune stimulation of S2 cells overexpressing PGRP-LF, we noticed a reduced up-regulation of expression of antimicrobial peptide genes, in consonance with an immune suppressive role for PGRP-LF.

Peptidoglycan recognition protein LF: a negative regulator of Drosophila immunity. Publishing Authors By Initials

C Persson,S Oldenvi,H Steiner,

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Peptidoglycan recognition protein LF: a negative regulator of Drosophila immunity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Insect biochemistry and molecular biology

VOLUME: 37

Page Numbers: 1309-16

Journal Abbreviation: Insect Biochem. Mol. Biol.

ISSN: 0965-1748

DAY: 21

MONTH: 08

YEAR: 2007

Peptidoglycan recognition protein LF: a negative regulator of Drosophila immunity. Information

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LANGUAGE: eng

NlmUniqueID: 9207282

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Grant and Affiliation Information for Peptidoglycan recognition protein LF: a negative regulator of Drosophila immunity.

AFFILIATION: Department of Genetics, Microbiology, and Toxicology, University of Stockholm, S-106 91 Stockholm, Sweden.

Country: England

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MEDLINETA: Insect Biochem Mol Biol

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