Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain.

Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain. Research Abstract Details 

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Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain. Abstract Text:

Neural progenitor proliferation, differentiation, and migration are continually ongoing processes in the subventricular zone (SVZ) and rostral migratory stream (RMS) of the adult brain. There is evidence that peptidergic systems may be involved in the molecular cascades regulating these neurogenic processes, and we examined a possible influence of neuropeptide Y (NPY) and cholecystokinin (CCK) systems in cell proliferation and neuroblast formation in the SVZ and RMS and generation of interneurons in the olfactory bulb (OB). We show that NPY and the Y1 and Y2 receptor (R) proteins are expressed in and surrounding the SVZ and RMS and that Y1R is located on neuroblasts in the anterior RMS. Mice deficient in Y1Rs or Y2Rs have fewer Ki-67-immunoreactive (ir) proliferating precursor cells and doublecortin-ir neuroblasts in the SVZ and RMS than WT mice, and less calbindin-, calretinin-, and tyrosine hydroxylase-ir interneurons in the OB. Mice lacking CCK1Rs have fewer proliferating cells and neuroblasts than normal and a shortage of interneurons in the OB. These findings suggest that both NPY and CCK through their receptors help to regulate the proliferation of precursor cells, the amount of neuroblast cells in the SVZ and RMS, and influence the differentiation of OB interneurons.

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Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 105

Page Numbers: 3610-5

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 1091-6490

DAY: 27

MONTH: 02

YEAR: 2008

Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

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Grant and Affiliation Information for Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain.

AFFILIATION: Department of Neuroscience, Karolinska Institutet, S-17177 Stockholm, Sweden.

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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