Peptide YY regulates bone turnover in rodents.

Peptide YY regulates bone turnover in rodents. Research Abstract Details 

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Peptide YY regulates bone turnover in rodents. Abstract Text:

Katherine E Wortley,Karen Garcia,Haruka Okamoto,Karen Thabet,Keith D Anderson,Victor Shen,Jim P Herman,David Valenzuela,George D Yancopoulos,Matthias H ,Andrew Murphy,Mark W Sleeman,Katherine E Wortley,Karen Garcia,Haruka Okamoto,Karen Thabet,Keith D Anderson,Victor Shen,Jim P Herman,David Valenzuela,George D Yancopoulos,Matthias H ,Andrew Murphy,Mark W Sleeman,

BACKGROUND & AIMS: Peptide YY (PYY) and pancreatic polypeptide (PPY) are members of the neuropeptide Y peptide family. The neuropeptide Y receptor signaling pathway has been implicated in a number of physiologic processes, including the regulation of energy balance and bone mass. To investigate the contribution of endogenous PYY and PPY to these processes, we generated both Pyy- and Ppy-deficient mice. METHODS: Pyy(-/-) and Ppy(-/-) mice and their respective wild-type littermates were studied from 8 weeks to 9 months of age. Food intake, metabolic parameters, and locomotor activity were monitored using indirect calorimetry. Body composition and bone parameters were analyzed using dual energy x-ray absorptiometry, histomorphometry, and vertebral compression testing. RESULTS: Studies in these mice showed an osteopenic phenotype specific to the Pyy-deficient line, which included a reduction in trabecular bone mass and a functional deficit in bone strength. Furthermore, female Pyy(-/-) mice showed a greater sensitivity to ovariectomy-induced bone loss compared with wild-type littermates. No food intake or metabolic phenotype was apparent in male or female Pyy(-/-) mice on standard chow. However, female Pyy(-/-) mice on a high-fat diet showed a greater propensity to gain body weight and adiposity. No metabolic or osteopenic phenotype was observed in Ppy-deficient mice. CONCLUSIONS: These results indicate that endogenous PYY plays a critical role in regulating bone mass. In comparison, its role in regulating body weight is minor and is confined to situations of high-fat feeding.

Peptide YY regulates bone turnover in rodents. Publishing Authors By Initials

KE Wortley,K Garcia,H Okamoto,K Thabet,KD Anderson,V Shen,JP Herman,D Valenzuela,GD Yancopoulos,MH ,A Murphy,MW Sleeman,KE Wortley,K Garcia,H Okamoto,K Thabet,KD Anderson,V Shen,JP Herman,D Valenzuela,GD Yancopoulos,MH ,A Murphy,MW Sleeman,

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Peptide YY regulates bone turnover in rodents. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Gastroenterology

VOLUME: 133

Page Numbers: 1534-43

Journal Abbreviation: Gastroenterology

ISSN: 1528-0012

DAY: 15

MONTH: 08

YEAR: 2007

Peptide YY regulates bone turnover in rodents. Information

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LANGUAGE: eng

NlmUniqueID: 374630

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AFFILIATION: Regeneron Pharmaceuticals Inc, Tarrytown, New York, USA.

Country: United States

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MEDLINETA: Gastroenterology

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