Peptide drug delivery into the central nervous system.

Peptide drug delivery into the central nervous system. Research Abstract Details 

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Peptide drug delivery into the central nervous system. Abstract Text:

The microvasculature of the central nervous system (CNS) is characterized by tight junctions between the endothelial cells and, thus, behaves as a continuous lipid bilayer that prevents the passage of polar and lipid-insoluble substances such as peptides. Highly active enzymes expressed in the morphological components of the microcirculation also represent a metabolic component that contributes to the homeostatic balance of the CNS. Peptides generally cannot enter the brain and spinal cord from the circulating blood because they are highly polar and lipid insoluble, metabolically unstable, and active transport systems only exist for very few of them in this membraneous barrier separating the systemic circulation from the interstitial fluid of the CNS. This blood-brain barrier is, therefore, the major obstacle to peptide-based drugs that are potentially useful for combating diseases affecting the brain and spinal cord. This review discusses and critically evaluates invasive, chemical-enzymatic (prodrug and chemical delivery/targeting system) and biological carrier-based approaches to overcome the blood-brain barrier for these highly active and versatile molecules that are very attractive as a future generation of neuropharmaceuticals.

Peptide drug delivery into the central nervous system. Publishing Authors By Initials

For similar pharmaceutical preparations: prodrugs research abstracts see: pharmaceutical preparations: prodrugs research

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Peptide drug delivery into the central nervous system. Journal Published:

PUBLICATION TYPE: Review

Journal: Progress in drug research. Fortschritte der Arznei

VOLUME: 51

Page Numbers: 95-131

Journal Abbreviation:

ISSN: 0071-786X

DAY: 25

MONTH: 02

YEAR: 1998

Peptide drug delivery into the central nervous system. Information

Number of References: 108

LANGUAGE: eng

NlmUniqueID: 1304021

Peptide drug delivery into the central nervous system. Keywords Mesh Terms:

KEYWORDS: Prodrugs

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Peptide drug delivery into the central nervous system. Information

Substance Name: Prodrugs

Registry Number: 0

Grant and Affiliation Information for Peptide drug delivery into the central nervous system.

AFFILIATION: Center for Drug Discovery, College of Pharmacy, University of Florida, J. Hillis Miller Health Center, Gainesville 32610-0497, USA.

Country: SWITZERLAND

AGENCY: United States NINDS

GRANT: R01 NS30616

ACRONYM: NS

MEDLINETA: Prog Drug Res

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