Peptide cytokines in CNS and the immune system.

Peptide cytokines in CNS and the immune system. Research Abstract Details 

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Peptide cytokines in CNS and the immune system. Abstract Text:

H ,H ,V Mares,F ,P Siman,

This study describes the effects of cytokine peptides released into the supernatant during an early allogeneic reaction (AR) of mouse spleen lymphocytes or brain cortex cells which differ in their major histocompatibility complex (MHC). The peptides were isolated by ultrafiltration, liquid chromatography and HPLC. We found that both peptides stimulated the cell surface Na+,K+-ATPase and Ca2+-ATPase activities of quiescent spleen lymphocytes in vitro and mimicked early allogeneic cell interactions. Both brain and spleen AR peptides inhibited Concanavalin A-stimulated spleen lymphocyte proliferation, whereas 3H-TdR incorporation into DNA of the E7 neuroblastoma cell line was stimulated by these peptides. The peptide isolated from the supernatant of the allogeneic brain cell reaction inhibited phagocytosis in phorbol myristate-stimulated LA5-9/8 mouse macrophage cell line. Immunosuppressive activity of spleen AR peptide is supported by inhibition of spontaneous E rosette formation by lymphocytes. The immunosuppressive effect of isolated peptide cytokines on lectin-activated lymphocytes was comparable with the serum thymic factor (FTS, Lenfant et al. 1983). These changes demonstrate the pleiotropic cytokine actions mediated by plasma membrane of immune system and brain cells.

Peptide cytokines in CNS and the immune system. Publishing Authors By Initials

H ,H ,V Mares,F ,P Siman,

For similar cells: cells, cultured: tumor cells, cultured research abstracts see: cells: cells, cultured: tumor cells, cultured research

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Peptide cytokines in CNS and the immune system. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Physiological research / Academia Scientiarum Bohe

VOLUME: 46

Page Numbers: 145-53

Journal Abbreviation: Physiol Res

ISSN: 0862-8408

DAY: 2

MONTH: 04

YEAR: 1997

Peptide cytokines in CNS and the immune system. Information

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LANGUAGE: eng

NlmUniqueID: 9112413

Peptide cytokines in CNS and the immune system. Keywords Mesh Terms:

KEYWORDS: Tumor Cells, Cultured

MESH TERMS: metabolism

Chemical & Substance for Abstract: Peptide cytokines in CNS and the immune system. Information

Substance Name: Sodium-Potassium-Exchanging ATPase

Registry Number: EC 3.6.3.9

Grant and Affiliation Information for Peptide cytokines in CNS and the immune system.

AFFILIATION: Institute of Microbiology, Academy of Sciences of the Czech Republic, Nový Hrádek, Czech Republic.

Country: CZECH REPUBLIC

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MEDLINETA: Physiol Res

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