Pediatric respiratory and systemic effects of chronic air pollution exposure: nose, lung, heart, and brain pathology.

Pediatric respiratory and systemic effects of chronic air pollution exposure: nose, lung, heart, and brain pathology. Research Abstract Details 

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Pediatric respiratory and systemic effects of chronic air pollution exposure: nose, lung, heart, and brain pathology. Abstract Text:

Lilian ,Maricela Franco-Lira,Ricardo ,Carlos ,Gerardo ,Gildardo Valencia-Salazar,Angelica ,Rafael Reynoso-Robles,Rafael ,William Reed,

Exposures to particulate matter and gaseous air pollutants have been associated with respiratory tract inflammation, disruption of the nasal respiratory and olfactory barriers, systemic inflammation, production of mediators of inflammation capable of reaching the brain and systemic circulation of particulate matter. Mexico City (MC) residents are exposed to significant amounts of ozone, particulate matter and associated lipopolysaccharides. MC dogs exhibit brain inflammation and an acceleration of Alzheimer's-like pathology, suggesting that the brain is adversely affected by air pollutants. MC children, adolescents and adults have a significant upregulation of cyclooxygenase-2 (COX2) and interleukin-1beta (IL-1beta) in olfactory bulb and frontal cortex, as well as neuronal and astrocytic accumulation of the 42 amino acid form of beta -amyloid peptide (Abeta 42), including diffuse amyloid plaques in frontal cortex. The pathogenesis of Alzheimer's disease (AD) is characterized by brain inflammation and the accumulation of Abeta 42, which precede the appearance of neuritic plaques and neurofibrillary tangles, the pathological hallmarks of AD. Our findings of nasal barrier disruption, systemic inflammation, and the upregulation of COX2 and IL-1beta expression and Abeta 42 accumulation in brain suggests that sustained exposures to significant concentrations of air pollutants such as particulate matter could be a risk factor for AD and other neurodegenerative diseases.

Pediatric respiratory and systemic effects of chronic air pollution exposure: nose, lung, heart, and brain pathology. Publishing Authors By Initials

L ,M Franco-Lira,R ,C ,G ,G Valencia-Salazar,A ,R Reynoso-Robles,R ,W Reed,

For similar population characteristics: health: urban health research abstracts see: population characteristics: health: urban health research

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Pediatric respiratory and systemic effects of chronic air pollution exposure: nose, lung, heart, and brain pathology. Journal Published:

PUBLICATION TYPE: Review

Journal: Toxicologic pathology

VOLUME: 35

Page Numbers: 154-62

Journal Abbreviation:

ISSN: 0192-6233

DAY: 3

MONTH: 12

YEAR: 2007

Pediatric respiratory and systemic effects of chronic air pollution exposure: nose, lung, heart, and brain pathology. Information

Number of References: 84

LANGUAGE: eng

NlmUniqueID: 7905907

Pediatric respiratory and systemic effects of chronic air pollution exposure: nose, lung, heart, and brain pathology. Keywords Mesh Terms:

KEYWORDS: Urban Health

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Pediatric respiratory and systemic effects of chronic air pollution exposure: nose, lung, heart, and brain pathology. Information

Substance Name: Particulate Matter

Registry Number: 0

Grant and Affiliation Information for Pediatric respiratory and systemic effects of chronic air pollution exposure: nose, lung, heart, and brain pathology.

AFFILIATION: Instituto Nacional de Pediatría, Mexico City, Mexico.

Country: United States

AGENCY: United States NCRR

GRANT: 5 P20 RR015583

ACRONYM: RR

MEDLINETA: Toxicol Pathol

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