Peak in matrix metaloproteinases-2 levels observed during recovery from olfactory nerve injury.

Peak in matrix metaloproteinases-2 levels observed during recovery from olfactory nerve injury. Research Abstract Details 

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Peak in matrix metaloproteinases-2 levels observed during recovery from olfactory nerve injury. Abstract Text:

Matrix metalloproteineases are associated with extracellular remodeling that occurs in injury and repair processes in the central nervous system (CNS). We examined the role of MMP-2 in a model of olfactory nerve injury and found that MMP-2 levels increased several hours following injury, peaked at day 7 and then decreased rapidly. We previously reported a rapid increase in MMP-9, within 5 h after nerve injury, corresponding to neuronal degeneration and increased glial activity. In this study, we show that MMP-2 peaks later than MMP-9, at the onset of neuronal regeneration and repair. Using MMP-9 knockout mice, we determined that the MMP-2 increase is independent of MMP-9. Our data suggest that MMP-2 and MMP-9 may play different roles in the injury and repair processes.

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Peak in matrix metaloproteinases-2 levels observed during recovery from olfactory nerve injury. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuroreport

VOLUME: 19

Page Numbers: 327-31

Journal Abbreviation: Neuroreport

ISSN: 0959-4965

DAY: 12

MONTH: Feb

YEAR: 2008

Peak in matrix metaloproteinases-2 levels observed during recovery from olfactory nerve injury. Information

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LANGUAGE: eng

NlmUniqueID: 9100935

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AFFILIATION: Department of Physiology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.

Country: England

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MEDLINETA: Neuroreport

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