PCB congener-specific disruption of reproductive neuroendocrine function in Atlantic croaker.

PCB congener-specific disruption of reproductive neuroendocrine function in Atlantic croaker. Research Abstract Details 

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PCB congener-specific disruption of reproductive neuroendocrine function in Atlantic croaker. Abstract Text:

Izhar A Khan,Peter Thomas,Izhar A Khan,Peter Thomas,

Exposure of Atlantic croaker to Aroclor 1254 has been shown to impair reproductive neuroendocrine function in this species. In addition, we have identified hypothalamic tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin synthesis, as a target of PCB neuroendocrine toxicity. A previous study in rats has implicated di-ortho-substituted non-coplanar PCB congeners in the inhibition of a similar enzyme, tyrosine hydroxylase, which is the rate-limiting enzyme in dopamine synthesis. Therefore, the present study was designed to investigate whether di-ortho-substituted congeners (PCB 47, PCB 153) or a coplanar congener (PCB 77) present in Aroclor 1254 could be responsible for the reproductive impairment observed in croaker exposed to the PCB mixture. Fish were exposed to PCB 47 and PCB 153 in the diet (0, 0.2 and 1.0 mg/kg body weight/day) for 30 days and to PCB 77 (0.01 and 0.1 mg/kg body weight/day) for 15 days. Neither PCB 47 nor PCB 153 altered hypothalamic TPH activity or gonadal growth at doses similar to the effective doses of the Aroclor 1254 mixture. Therefore, these ortho-substituted PCB congeners known to be neurotoxic in mammalian systems are unlikely to contribute to Aroclor 1254-induced reproductive neuroendocrine disruption in croaker. In contrast, PCB 77 significantly inhibited hypothalamic TPH activity and gonadal growth at doses much lower than the effective doses of Aroclor 1254. The results provide the first evidence for PCB congener-specific disruption of reproductive neuroendocrine function in a vertebrate species.

PCB congener-specific disruption of reproductive neuroendocrine function in Atlantic croaker. Publishing Authors By Initials

IA Khan,P Thomas,IA Khan,P Thomas,

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PCB congener-specific disruption of reproductive neuroendocrine function in Atlantic croaker. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Marine environmental research

VOLUME: 62 Suppl

Page Numbers: S25-8

Journal Abbreviation: Mar. Environ. Res.

ISSN: 0141-1136

DAY: 18

MONTH: 04

YEAR: 2006

PCB congener-specific disruption of reproductive neuroendocrine function in Atlantic croaker. Information

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LANGUAGE: eng

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Grant and Affiliation Information for PCB congener-specific disruption of reproductive neuroendocrine function in Atlantic croaker.

AFFILIATION: The University of Texas at Austin, Marine Science Institute, Port Aransas, TX 78373, USA. ikhan@utmsi.utexas.edu

Country: England

AGENCY: United States NIEHS

GRANT: ES07672

ACRONYM: ES

MEDLINETA: Mar Environ Res

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