Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells.

Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells. Research Abstract Details 

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Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells. Abstract Text:

Hiroshi Tamai,Hiroshi Shinohara,Takaki Miyata,Kanako Saito,Yuji Nishizawa,Tadashi Nomura,Noriko Osumi,

The mammalian cerebral cortex develops from proliferative neuroepithelial cells that exhibit a cell cycle-dependent nuclear movement (interkinetic nuclear migration; INM). Pax6 transcription factor plays pivotal roles in various aspects of corticogenesis. From live observation using cultured cortical slices from the Pax6 mutant rat, we identified the premature descent of S phase cells, the unsteady ascent or descent of G2 phase cells, and ectopic cell division within the basal side of the ventricular zone (VZ). The centrosome normally stayed at the most apical side, apart from the nucleus, in the neuroepithelial cell during the S to G2 phase, while the Pax6 mutant showed unstable movement of the centrosome associated with an abnormal INM. Our results suggest the possibility that Pax6 regulates the INM by stabilizing the centrosome at the apical side.

Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells. Publishing Authors By Initials

H Tamai,H Shinohara,T Miyata,K Saito,Y Nishizawa,T Nomura,N Osumi,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell cycle: interphase: s phase research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell cycle: interphase: s phase research

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Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genes to cells : devoted to molecular & cellular m

VOLUME: 12

Page Numbers: 983-96

Journal Abbreviation: Genes Cells

ISSN: 1356-9597

DAY: 27

MONTH: Sep

YEAR: 2007

Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells. Information

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LANGUAGE: eng

NlmUniqueID: 9607379

Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells. Keywords Mesh Terms:

KEYWORDS: S Phase

MESH TERMS: physiology

Chemical & Substance for Abstract: Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells. Information

Substance Name: Repressor Proteins

Registry Number: 0

Grant and Affiliation Information for Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells.

AFFILIATION: Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

Country: England

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MEDLINETA: Genes Cells

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