Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.

Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Research Abstract Details 

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Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Abstract Text:

Xin Zhang,Sheldon Rowan,Yingzi Yue,Shaun Heaney,Yi Pan,Andrea Brendolan,Licia Selleri,Richard L Maas,

Pancreatic development depends on the transcription factor Pax6, which controls islet cell differentiation and hormone production. To understand the regulation of Pax6 pancreatic expression, we have identified a minimal Pax6 pancreatic enhancer and show that it contains a composite binding site for Meis and Pbx homeoproteins. We further show that Meis proteins are expressed during pancreatic development, and together with Pbx, are able to form a synergistic binding complex on the Pax6 pancreatic enhancer. When tested in transgenic mice, both the Meis and Pbx sites are essential for Pax6 pancreatic enhancer activity, and the composite site can be functionally replaced by a consensus Meis-Pbx sequence. In addition, analysis of Pbx1 and Pbx2 knockout mice demonstrates that, during pancreatic islet formation, Pax6 expression becomes dependent upon Pbx1 and Pbx2 function. As Meis homeoproteins have been previously demonstrated to regulate Pax6 expression during lens development, these results suggest a conserved mechanism of Pax6 regulation by Meis homeoproteins in two different organs.

Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Publishing Authors By Initials

X Zhang,S Rowan,Y Yue,S Heaney,Y Pan,A Brendolan,L Selleri,RL Maas,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental biology

VOLUME: 300

Page Numbers: 748-57

Journal Abbreviation: Dev. Biol.

ISSN: 0012-1606

DAY: 27

MONTH: 06

YEAR: 2006

Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Information

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LANGUAGE: eng

NlmUniqueID: 372762

Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: physiology

Chemical & Substance for Abstract: Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Information

Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.

AFFILIATION: Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 W. Walnut St., IB244, Indianapolis, IN 46202, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R01 DK065791

ACRONYM: DK

MEDLINETA: Dev Biol

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