Pax6 directly modulate Sox2 expression in the neural progenitor cells.

Pax6 directly modulate Sox2 expression in the neural progenitor cells. Research Abstract Details 

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Pax6 directly modulate Sox2 expression in the neural progenitor cells. Abstract Text:

Jinhua Wen,Qikuan Hu,Meiyu Li,Shuling Wang,Lirong Zhang,Yuanyuan Chen,Lingsong Li,

Pax6 is a key regulator in the neuronal fate determination as well as the proliferation of neural stem cells, but the mechanisms are still unknown. Our study shows that Pax6 regulate the proliferation of neural progenitor cells of cortical subventricular zone, through direct modulation of the Sox2 expression during the late developmental stage in mice. We found a dramatic decrease in the number of Sox2 neural progenitor cells in the subventricular zone of E18.5 Pax6 mice. We confirmed that Pax6 could bind to the Sox2 promoter by chromatin immunoprecipitation assay and activate Sox2 expression by a luciferase reporter gene assay. Moreover, neural progenitors isolated from the Pax6 embryos showed a decreased neurosphere formation as well as proliferation.

Pax6 directly modulate Sox2 expression in the neural progenitor cells. Publishing Authors By Initials

J Wen,Q Hu,M Li,S Wang,L Zhang,Y Chen,L Li,

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Pax6 directly modulate Sox2 expression in the neural progenitor cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuroreport

VOLUME: 19

Page Numbers: 413-7

Journal Abbreviation: Neuroreport

ISSN: 0959-4965

DAY: 4

MONTH: Mar

YEAR: 2008

Pax6 directly modulate Sox2 expression in the neural progenitor cells. Information

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LANGUAGE: eng

NlmUniqueID: 9100935

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Grant and Affiliation Information for Pax6 directly modulate Sox2 expression in the neural progenitor cells.

AFFILIATION: aPeking University Stem Cell Research Center and Cell Biology Department, Peking University Health Science Center, Beijing bBrain Research Lab of Ningxia, Ningxia Medical College, Yinchuan, China.

Country: England

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MEDLINETA: Neuroreport

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