Paucity of pericytes in germinal matrix vasculature of premature infants.

Paucity of pericytes in germinal matrix vasculature of premature infants. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Paucity of pericytes in germinal matrix vasculature of premature infants. Abstract Text:

Alex Braun,Hongmin Xu,Furong Hu,Praneeth Kocherlakota,Donald Siegel,Praveen Chander,Zoltan Ungvari,Anna Csiszar,Maiken Nedergaard,Praveen Ballabh,

Germinal matrix (GM) is a richly vascularized collection of neuronal-glial precursor cells in the developing brain, which is selectively vulnerable to hemorrhage in premature infants. It has rapid angiogenesis associated with high levels of vascular endothelial growth factor (VEGF). Because pericytes provide structural stability to blood vessels, we asked whether pericytes were fewer in the GM than in the subjacent white matter and neocortex and, if so, whether angiogenic inhibition could increase the pericyte density in the GM. We found pericyte coverage and density less in the GM vasculature than in the cortex or white matter in human fetuses, premature infants, and premature rabbit pups. Notably, although VEGF suppression significantly enhanced pericyte coverage in the GM, it remained less than in other brain regions. Therefore, to further elucidate the basis of fewer pericytes in the GM vasculature, we examined expression of ligand-receptor systems responsible for pericyte recruitment. Transforming growth factor-beta1 (TGF-beta1) protein expression was lower, whereas sphingosine-1-phosphate1 (S1P1) and N-cadherin levels were higher in the GM than in the cortex or white matter. Low TGF-beta1 may be involved in promoting endothelial proliferation, whereas elevated S1P1 with N-cadherin may assist vascular maturation. Hence, a paucity of pericytes in the GM vasculature may contribute to its propensity to hemorrhage, and a lower expression of TGF-beta1 could be a basis of reduced pericyte density in its vasculature.

Paucity of pericytes in germinal matrix vasculature of premature infants. Publishing Authors By Initials

A Braun,H Xu,F Hu,P Kocherlakota,D Siegel,P Chander,Z Ungvari,A Csiszar,M Nedergaard,P Ballabh,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Paucity of pericytes in germinal matrix vasculature of premature infants. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 12012-24

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 31

MONTH: Oct

YEAR: 2007

Paucity of pericytes in germinal matrix vasculature of premature infants. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102140

Paucity of pericytes in germinal matrix vasculature of premature infants. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Paucity of pericytes in germinal matrix vasculature of premature infants. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Paucity of pericytes in germinal matrix vasculature of premature infants.

AFFILIATION: Department of Pathology, New York Medical College, Westchester Medical Center, Valhalla, New York 10595, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS050586

ACRONYM: NS

MEDLINETA: J Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Paucity of pericytes in germinal matrix vasculature of premature infants Related Publications

• Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasone.
• Paucity of pericytes in germinal matrix vasculature of premature infants.