Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation.

Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation. Research Abstract Details 

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Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation. Abstract Text:

Cielito C Reyes-Gibby,Wenyaw Chan,James L Abbruzzese,Henry Q Xiong,Linus Ho,Douglas B Evans,Gauri Varadhachary,Samrat Bhat,Robert A Wolff,Christopher Crane,

Pancreatic cancer is a lethal disease characterized by multiple disease-related symptoms. Chemoradiation therapy is a standard of treatment for locally advanced pancreatic cancer. Although shown to prolong survival, there is little information about treatment-related symptoms or the palliative benefits of chemoradiation. We assessed symptoms of patients with locally advanced pancreatic cancer receiving chemoradiation to determine the prevalence, and co-occurrence, of symptoms and to identify the extent to which symptoms interfered with function. Forty-eight patients were treated with chemoradiation on a Phase I protocol. Patients received radiotherapy (50.4 Gy in 28 fractions), capecitabine (median dose 825 mg/m(2) twice daily), and bevacizumab (2.5-10 mg/kg). Symptom severity and its interference with function were prospectively assessed (at presentation, during, and after chemoradiation) in 43 consenting patients using the M.D. Anderson Symptom Inventory. Results showed that 95% of patients reported at least one of the 13 symptoms assessed at presentation. The most commonly reported symptoms of moderate to severe (>or=5 on a 0-10 scale) intensity at presentation were lack of appetite (24%), pain (19%), fatigue (19%), and sleep disturbance (10%). We observed an increase in patients reporting moderate to severe fatigue, nausea, and sleep disturbance during chemoradiation. McNemar tests for paired binary observations showed the proportion of patients reporting moderate to severe symptoms significantly (P<0.001) decreased after chemoradiation at 94 days follow-up (lack of appetite=7%, pain=7%, fatigue=13%, sleep disturbance=7%). This study demonstrates the feasibility and usefulness of symptom assessment in chemoradiation protocols. Future studies with larger cohorts are needed to further characterize multiple symptoms associated with chemoradiation.

Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation. Publishing Authors By Initials

CC Reyes-Gibby,W Chan,JL Abbruzzese,HQ Xiong,L Ho,DB Evans,G Varadhachary,S Bhat,RA Wolff,C Crane,

For similar nervous system diseases: sleep disorders research abstracts see: nervous system diseases: sleep disorders research

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Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of pain and symptom management

VOLUME: 34

Page Numbers: 244-52

Journal Abbreviation:

ISSN: 0885-3924

DAY: 21

MONTH: 05

YEAR: 2007

Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8605836

Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation. Keywords Mesh Terms:

KEYWORDS: Sleep Disorders

MESH TERMS: etiology

Chemical & Substance for Abstract: Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation. Information

Substance Name: Antineoplastic Agents

Registry Number: 0

Grant and Affiliation Information for Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation.

AFFILIATION: Department of Epidemiology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4009, USA. creyes@mdanderson.org

Country: United States

AGENCY: United States NCI

GRANT: K07 CA109043-01

ACRONYM: CA

MEDLINETA: J Pain Symptom Manage

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