Patterns and predictors of physical functional disability at 5 to 10 years after heart transplantation.

Patterns and predictors of physical functional disability at 5 to 10 years after heart transplantation. Research Abstract Details 

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Patterns and predictors of physical functional disability at 5 to 10 years after heart transplantation. Abstract Text:

Kathleen L Grady,David C Naftel,James B Young,Dave Pelegrin,Jennifer Czerr,Robert Higgins,Alain Heroux,Bruce Rybarczyk,Mary McLeod,Jon Kobashigawa,Julie Chait,Connie White-Williams,Susan Myers,James K Kirklin,

BACKGROUND: Researchers have not examined relationships between perception of physical functional disability and demographic, clinical, and psychological variables at 5 to 10 years after heart transplantation. Therefore, the purposes of this study were to describe physical functional disability over time and identify predictors of physical functional disability from 5 to 10 years after heart transplantation. METHODS: The study enrolled 555 patients who were between 5 and 10 years post-heart transplant (age, 54 +/- 9 years; 78% male, 88% white, 79% married). Patients completed 6 instruments that measure physical functional disability and factors that may impact physical functional disability. Statistical analyses included calculation of frequencies, means +/- standard deviation (plotted over time), Pearson correlation coefficients, and multiple regression coupled with repeated measures. RESULTS: Between 5 and 10 years after heart transplantation, physical functional disability was low, and 34% to 45% of patients reported having no functional disability. More physical functional disability was associated with having more symptoms, having depression/mood/negative affect and lower use of negative coping strategies, having more comorbidities and more specific comorbidities (e.g., more orthopedic problems and diabetes); higher New York Heart Association functional class; having more acute rejection, infection, or cardiac allograft vasculopathy; being female, older, less educated, and unemployed; higher body mass index; and more hospital readmissions (explaining 46% of variance [F = 84.75, p < 0.0001]). CONCLUSIONS: Demographic, clinical, and psychological factors were significantly related to physical functional disability. Knowledge of these factors provides the basis for development of therapeutic plans of care.

Patterns and predictors of physical functional disability at 5 to 10 years after heart transplantation. Publishing Authors By Initials

KL Grady,DC Naftel,JB Young,D Pelegrin,J Czerr,R Higgins,A Heroux,B Rybarczyk,M McLeod,J Kobashigawa,J Chait,C White-Williams,S Myers,JK Kirklin,

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Patterns and predictors of physical functional disability at 5 to 10 years after heart transplantation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of heart and lung transplantation : th

VOLUME: 26

Page Numbers: 1182-91

Journal Abbreviation: J. Heart Lung Transplant.

ISSN: 1557-3117

DAY: 27

MONTH: 09

YEAR: 2007

Patterns and predictors of physical functional disability at 5 to 10 years after heart transplantation. Information

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LANGUAGE: eng

NlmUniqueID: 9102703

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Grant and Affiliation Information for Patterns and predictors of physical functional disability at 5 to 10 years after heart transplantation.

AFFILIATION: Northwestern Memorial Hospital, Chicago, Illinois, USA. kgrady@nmh.org

Country: United States

AGENCY: United States NINR

GRANT: R01 NR005200

ACRONYM: NR

MEDLINETA: J Heart Lung Transplant

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