Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels.

Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Research Abstract Details 

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Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Abstract Text:

Immunoglobulin A (IgA) nephropathy is the most prevalent form of glomerulonephritis worldwide. A renal biopsy is required for an accurate diagnosis, as no convenient biomarker is currently available. We developed a serological test based upon the observation that this nephropathy is characterized by undergalactosylated IgA1 in the circulation and in mesangial immune deposits. In the absence of galactose, the terminal saccharide of O-linked chains in the hinge region of IgA1 is terminal or sialylated N-acetylgalactosamine. A lectin from Helix aspersa, recognizing N-acetylgalactosamine, was used to develop an enzyme-linked immunosorbent assay that measures galactose-deficient IgA1 in serum. The median serum lectin-binding IgA1 level was significantly higher for 153 Caucasian adult patients with IgA nephropathy without progression to end-stage renal disease as compared with that for 150 healthy Caucasian adult controls. As the lectin-binding IgA1 levels for the controls were not normally distributed, the 90th percentile was used for determination of significant elevation. Using a value of 1076 U/ml as the upper limit of normal, 117 of the 153 patients with IgA nephropathy had an elevated serum lectin-binding IgA1 level. The sensitivity as a diagnostic test was 76.5%, with specificity 94%; the positive predictive value was 88.6% and the negative predictive value was 78.9%. We conclude that this lectin-binding assay may have potential as a noninvasive diagnostic test for IgA nephropathy.

Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Publishing Authors By Initials

For similar investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research

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Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Kidney international

VOLUME: 71

Page Numbers: 1148-54

Journal Abbreviation: Kidney Int.

ISSN: 0085-2538

DAY: 7

MONTH: 03

YEAR: 2007

Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 323470

Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Keywords Mesh Terms:

KEYWORDS: Sensitivity and Specificity

MESH TERMS: metabolism

Chemical & Substance for Abstract: Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Information

Substance Name: Acetylgalactosamine

Registry Number: 31022-50-1

Grant and Affiliation Information for Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels.

AFFILIATION: Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

Country: United States

AGENCY: United States NCRR

GRANT: M01 RR00211

ACRONYM: RR

MEDLINETA: Kidney Int

REFSOURCE: Kidney Int. 2007 Jun;71(11):1089-91

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