Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1.

Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1. Research Abstract Details 

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Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1. Abstract Text:

Rachel L Sabado,Ethan Babcock,Daniel G Kavanagh,Veronica Tjomsland,Bruce D Walker,Jeffrey D Lifson,Nina Bhardwaj,Marie Larsson,

The outcome following HIV infection depends on the nature and durability of the HIV-specific T cell response induced initially. The activation of protective T cell responses depends upon dendritic cells (DC), antigen-presenting cells which have the capacity to process and present viral antigens. DC pulsed with aldrithiol-2-inactivated HIV and delivered in vivo were reported to induce immune responses and promote virologic control in chronically HIV-1-infected subjects. To gain an understanding of this phenomenon, we characterized the steps involved in the presentation of antigens derived from aldrithiol-2-treated vs. infectious HIV-1 by DC. Antigen presentation, on both MHC class I and II, was independent of DC-specific ICAM-3-grabbing integrin, DEC-205 and macrophage mannose receptor, C-type lectins expressed by the DC. Inhibitor studies showed that presentation on MHC class I was dependent on viral fusion in a CD4/coreceptor-dependent manner, both at the cell surface and within endosomes, and access to the classical endosomal processing pathway. MHC class II presentation of HIV-associated antigens was dependent on active endocytosis, probably receptor-mediated, and subsequent degradation of virions in acidified endosomes in the DC. Our study brings forth new facts regarding the binding, uptake, and processing of chemically inactivated virions leading to efficient antigen presentation and should aid in the design of more effective HIV vaccines.

Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1. Publishing Authors By Initials

RL Sabado,E Babcock,DG Kavanagh,V Tjomsland,BD Walker,JD Lifson,N Bhardwaj,M Larsson,

For similar viruses: virion research abstracts see: viruses: virion research

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Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of immunology

VOLUME: 37

Page Numbers: 1752-63

Journal Abbreviation: Eur. J. Immunol.

ISSN: 0014-2980

DAY: 3

MONTH: Jul

YEAR: 2007

Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1273201

Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1. Keywords Mesh Terms:

KEYWORDS: Virion

MESH TERMS: immunology

Chemical & Substance for Abstract: Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1. Information

Substance Name: 2,2'-Dipyridyl

Registry Number: 366-18-7

Grant and Affiliation Information for Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1.

AFFILIATION: Department of Medicine and Pathology, School of Medicine, New York University, NY, USA.

Country: Germany

AGENCY: United States NCI

GRANT: N01 CO12400

ACRONYM: CO

MEDLINETA: Eur J Immunol

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