A total of 25 pregnant goats without neutralizing antibodies against BVD virus were inoculated with two different pestivirus isolates at eight different stages of gestation. In both infection groups, various malformations were observed in fetuses and neonates. In three twins with neutralizing antibodies against BVD virus leukoencephalomalacia occurred, characterized by gelatinous transformation in the cerebral hemispheres. These lesions were comparable to alterations described in alternative pathology of Border disease in sheep. Although the immunohistological findings are characteristic for immunological tolerance and viral persistence, viable offspring persistently infected with pestivirus was not observed.
Pathomorphological and immunohistological findings in progeny of goats experimentally infected with pestiviruses. Publishing Authors By Initials
Pathomorphological and immunohistological findings in progeny of goats experimentally infected with pestiviruses. Information
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LANGUAGE: eng
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Pathomorphological and immunohistological findings in progeny of goats experimentally infected with pestiviruses. Keywords Mesh Terms:
KEYWORDS: Togaviridae Infections
MESH TERMS: veterinary
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Grant and Affiliation Information for Pathomorphological and immunohistological findings in progeny of goats experimentally infected with pestiviruses.
AFFILIATION: Institute of Pathology, School of Veterinary Medicine, Hannover, Germany.
Country: GERMANY
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MEDLINETA: Zentralbl Veterinarmed B
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