Pathomechanism of entrapment neuropathy in diabetic and nondiabetic rats reared in wire cages.

Pathomechanism of entrapment neuropathy in diabetic and nondiabetic rats reared in wire cages. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Pathomechanism of entrapment neuropathy in diabetic and nondiabetic rats reared in wire cages. Abstract Text:

Toshiko Nishimura,Hitoshi Hirata,Masaya Tsujii,Ryu Iida,Yoko Hoki,Takahiro Iino,Satoru Ogawa,Atsumasa Uchida,Toshiko Nishimura,Hitoshi Hirata,Masaya Tsujii,Ryu Iida,Yoko Hoki,Takahiro Iino,Satoru Ogawa,Atsumasa Uchida,

To examine the pathomechanism of entrapment neuropathy associated with diabetes with special emphasis on the roles of mast cells and Tenascin-C using a rat model of Streptozotocin-induced diabetes. The roles of mast cells and Tenascin-C in development of tarsal tunnel syndrome were analyzed electrophysiologically and histologically in 20 male Ws/Ws-/-rats (mast cell deficient) and 20 of their male wild type counterparts (12-16 weeks old; 250-300 g). Rats were assigned randomly to one of the following three groups; diabetic group and nondiabetic group reared in cages with a wire grid flooring; non-diabetic group in cages with sawdust covered plastic flooring. No significant role for mast cells in entrapment neuropathy was found in the rats with streptozotocin-induced diabetes. Distal latency was prolonged in diabetic rats compared with nondiabetic rats, and positively correlated with increases in blood glucose levels. Tenascin-C expression levels in the endoneurium at the tarsal tunnel in diabetic rats were found to be correlated with distal latency. The anti-alpha-smooth muscle actin (alpha-SMA) positive myofibroblast was scattered in nerve fascicles overexpressing Tenascin-C. It seems likely that Tenascin-C expressing myofibroblasts constrict axons by inducing collagen contraction of the endoneurium. Our data indicate that metabolic and phenotypic abnormalities of endoneurium and perineum lie behind the vulnerability of diabetic patients to entrapment neuropathy.

Pathomechanism of entrapment neuropathy in diabetic and nondiabetic rats reared in wire cages. Publishing Authors By Initials

T Nishimura,H Hirata,M Tsujii,R Iida,Y Hoki,T Iino,S Ogawa,A Uchida,T Nishimura,H Hirata,M Tsujii,R Iida,Y Hoki,T Iino,S Ogawa,A Uchida,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Pathomechanism of entrapment neuropathy in diabetic and nondiabetic rats reared in wire cages. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Histology and histopathology

VOLUME: 23

Page Numbers: 157-66

Journal Abbreviation:

ISSN: 1699-5848

DAY: 13

MONTH: Feb

YEAR: 2008

Pathomechanism of entrapment neuropathy in diabetic and nondiabetic rats reared in wire cages. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8609357

Pathomechanism of entrapment neuropathy in diabetic and nondiabetic rats reared in wire cages. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Pathomechanism of entrapment neuropathy in diabetic and nondiabetic rats reared in wire cages. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Pathomechanism of entrapment neuropathy in diabetic and nondiabetic rats reared in wire cages.

AFFILIATION: Department of Orthopaedic Surgery, Mie University Faculty of Medicine, Tsu, Mie, Japan. nishit41@pref.mie.jp

Country: Spain

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Histol Histopathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Pathomechanism of entrapment neuropathy in diabetic and nondiabetic rats reared in wire cages Related Publications

• Acetabular reconstruction using a cementless cup and hydroxyapatite granules: 3- to 8-year clinical results.
• Amplicon profiling reveals cytoplasmic overexpression of MUC1 protein as an indicator of resistance to platinum-based chemotherapy in patients with ovarian cancer.
• Barttin binds to the outer lateral surface of the ClC-K2 chloride channel.
• Clinicopathological features of canine neuroaxonal dystrophy and cerebellar cortical abiotrophy in papillon and papillon-related dogs.
• Detection of neurotrophic factors in taste buds by laser capture microdissection, immunohistochemistry, and in situ hybridization.
• Effect of tourniquet application on deep vein thrombosis after total knee arthroplasty.
• Effects of quinine on the intracellular calcium level and membrane potential of PC 12 cultures.
• Electronic medical records and prevention quality: the prevention index.
• Evaluation of Spasticity in the Ankle of a Hemiplegic Subject using a Step-like Response.
• Fabrication of nanofibrous inhaler device.
• Field-size dependence of doses of therapeutic carbon beams.
• Flash wave light strongly enhanced the cytocidal effect of photodynamic therapy with acridine orange on a mouse osteosarcoma cell line.
• Genetic diversity and the genetic structure of natural populations of Chamaecyparis obtusa: implications for management and conservation.
• Immunochemical properties of ribonuclease T1 in relation to other ribonucleases.
• Inhibitory effect of aroma on the bitterness of branched-chain amino acid solutions.
• Learning what feelings to desire: socialization of ideal affect through children's storybooks.
• Molecular identification of Anisakis simplex sensu stricto and Anisakis pegreffii (Nematoda: Anisakidae) from fish and cetacean in Japanese waters.
• Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model.
• New Cleavage Methods for Cardiac Glycosides having a Doubly Linked Sugar1.
• Pathomechanism of entrapment neuropathy in diabetic and nondiabetic rats reared in wire cages.
• Purification and properties of RNase T2.
• Quantitative evaluation of spasticity in upper limbs in hemiplegic subject using a mathmatical model.
• Spatiotemporal Expression of Ameloblastin Isoforms during Murine Tooth Development.
• The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma.
• The laparoscopic approach of neuroblastoma.
• The suppression of enhanced bitterness intensity of macrolide dry syrup mixed with an acidic powder.
• [Development of the QA/QC-tools for CT number calibration of the treatment planning CT-scanner.]
• [Experimental Studies on Load Supporting Ability of Implant-retained Overdentures--Influence of Triangular Gaps' State of Magnetic Attachment for Implant-retained Overdentures on Load Supporting Ability.]
• [Removal of infected pacemaker leads under extracorporeal circulation]
• [Smoking cessation treatment, analysis of smoking cessation rate, and the reason of lower smoking cessation rate in women compared with that in men]