Pathology of immunodeficient mice with naturally occurring murine norovirus infection.

Pathology of immunodeficient mice with naturally occurring murine norovirus infection. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Pathology of immunodeficient mice with naturally occurring murine norovirus infection. Abstract Text:

Jerrold M Ward,Christiane E Wobus,Larissa B Thackray,Cindy R Erexson,Larry J Faucette, Belliot,Elyssa L Barron,Stanislav V Sosnovtsev,Kim Y Green,

Murine norovirus (MNV) was recently discovered in Rag2-/-/Stat1-/- mice in a U.S. medical research facility. Presently, little is known concerning the epidemiology and natural history of this virus. We studied the pathology of naturally occurring MNV infection in 28 immunodeficient mice of several different genotypes (Rag1-/-/IFNgamma R-/-, OT1 Rag1-/-/IFNgamma R-/-, OT2 Rag1-/-/IFNgamma R-/-, Rag1-/-/Stat1-/-, and Rag2-/-) that were maintained in two U.S. research facilities. The mice were selected for study because sentinel mice housed in their holding rooms had been identified as positive for MNV-specific antibodies during routine screening for infectious agents. Our data indicate that in certain lines of immunodeficient mice, MNV can establish a disseminated infection that is characteristically associated with inflammation in multiple tissues, including liver (hepatitis), lung (focal interstitial pneumonia) and the peritoneal and pleural cavities. In addition, MNV can establish an asymptomatic infection in the mesenteric lymph nodes of Rag2-/- mice. Further studies are needed to determine whether MNV presents a confounding variable in immunological, toxicological and pathological studies in mice naturally infected with MNV.

Pathology of immunodeficient mice with naturally occurring murine norovirus infection. Publishing Authors By Initials

JM Ward,CE Wobus,LB Thackray,CR Erexson,LJ Faucette,G Belliot,EL Barron,SV Sosnovtsev,KY Green,

For similar tissues: lymphoid tissue: spleen research abstracts see: tissues: lymphoid tissue: spleen research

PUBMED ID PMID:

MEDLINE DATE:

Pathology of immunodeficient mice with naturally occurring murine norovirus infection. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Toxicologic pathology

VOLUME: 34

Page Numbers: 708-15

Journal Abbreviation:

ISSN: 0192-6233

DAY: 3

MONTH: 12

YEAR: 2006

Pathology of immunodeficient mice with naturally occurring murine norovirus infection. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7905907

Pathology of immunodeficient mice with naturally occurring murine norovirus infection. Keywords Mesh Terms:

KEYWORDS: Spleen

MESH TERMS: pathology

Chemical & Substance for Abstract: Pathology of immunodeficient mice with naturally occurring murine norovirus infection. Information

Substance Name: interferon gamma receptor

Registry Number: 0

Grant and Affiliation Information for Pathology of immunodeficient mice with naturally occurring murine norovirus infection.

AFFILIATION: Infectious Disease Pathogenesis Section, Comparative Medicine Branch, Division of Intramural Research, NIAID, NIH, Twinbrook III, Bethesda, Maryland 20892-8135, USA. jeward@mail.nih.gov

Country: United States

AGENCY: United States PHS

GRANT: U54 A1057160

ACRONYM: AI

MEDLINETA: Toxicol Pathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Pathology of immunodeficient mice with naturally occurring murine norovirus infection Related Publications

• A comparison of multi-layer neural network and logistic regression in hereditary non-polyposis colorectal cancer risk assessment.
• After 30 years ... the future of hydroxyacids.
• An analysis of categorical perception of facial emotion in schizophrenia.
• Antifertility effect of busulfan and DL-6-(N-2-pipecolinomethyl)-5-hydroxy-indane maleate (PMHI) in coyotes (Canis Latrans ).
• Apoptosis of epitope-specific antiretroviral cytotoxic T lymphocytes via Fas ligand-Fas interactions.
• Buccal cells as biomarkers of fat intake.
• Clozapine use and relapses of substance use disorder among patients with co-occurring schizophrenia and substance use disorders.
• Coordinative organization of lingual propulsion during the normal adult swallow.
• Corneal endothelial injury thresholds for exposures to 1.54 micro m radiation.
• Disorders of extreme stress (DESNOS) symptoms are associated with type and severity of interpersonal trauma exposure in a sample of healthy young women.
• Effects of adrenalectomy on serum concentrations of progesterone during the luteal phase of sheep.
• Emergency department access to a longitudinal medical record.
• Exploring the short term visual store in schizophrenia using the attentional blink.
• Fas-mediated apoptosis and sphingomyelinase signal transduction: the role of ceramide as a second messenger for apoptosis.
• Future randomized trials for non small-cell lung cancer.
• Genetic manipulation of circadian rhythms in Xenopus.
• Heterotopic endochondrial ossification with mixed tumor formation in C3(1)/Tag transgenic mice is associated with elevated TGF-beta1 and BMP-2 expression.
• Inhibition of ceramide-induced apoptosis by Bcl-2.
• LC-MS analysis of carbonyl compounds and their occurrence in diesel emissions.
• Lingual heat and cold sensitivity following exposure to capsaicin or menthol.
• Molecular cloning and developmental expression of Par-1/MARK homologues XPar-1A and XPar-1B from Xenopus laevis.
• Pathology of immunodeficient mice with naturally occurring murine norovirus infection.
• Phase II trial of irinotecan/gemcitabine as second-line therapy for relapsed and refractory small-cell lung cancer: Cancer and Leukemia Group B Study 39902.
• Quantitative trait loci analysis of mice administered the methionine-choline deficient dietary model of experimental steatohepatitis.
• Structure/function analysis of Xenopus cryptochromes 1 and 2 reveals differential nuclear localization mechanisms and functional domains important for interaction with and repression of CLOCK-BMAL1.
• The abl oncogene family and apoptosis.
• The effects of the ARC organizational intervention on caseworker turnover, climate, and culture in children's service systems.
• The psychophysical relationship between bitter taste and burning sensation: evidence of qualitative similarity.
• Tissue remodeling during maturation of the Drosophila wing.
• Toxicology and drug testing in aviation.