Pathogenesis of serratial infection: activation of the Hageman factor-prekallikrein cascade by serratial protease.

Pathogenesis of serratial infection: activation of the Hageman factor-prekallikrein cascade by serratial protease. Research Abstract Details 

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Pathogenesis of serratial infection: activation of the Hageman factor-prekallikrein cascade by serratial protease. Abstract Text:

K Matsumoto,T Yamamoto,R Kamata,H Maeda,

A serratial protease with an apparent molecular weight of 56,000 (56K protease), which had been purified from the culture supernatant of a strain of Serratia marcescens isolated from a corneal lesion of a human eye [Matsumoto, K. et al. (1984) J. Bacteriol. 157, 225-232], greatly enhanced vascular permeability when injected into guinea pig skin. The 56K protease, which requires zinc ion for activity, was found to possess plasma kallikrein-like properties in vitro as judged by (i) preferential amidolysis of carbobenzoxy-Phe-Arg-4-methylcoumaryl-7-amide and Pro-Phe-Arg-4-methylcoumaryl-7-amide, which are known substrates for plasma kallikrein; (ii) release of kinin from high-molecular-weight kininogen; and (iii) prompt activation of Hageman factor followed by generation of kallikrein from plasma prekallikrein. These results suggest that the 56K protease enhances vascular permeability through activation of a Hageman factor-kallikrein-kinin pathway in vivo, and this molecular process appears to be a rational mechanism of enhancement of permeability and serratial pathogenesis.

Pathogenesis of serratial infection: activation of the Hageman factor-prekallikrein cascade by serratial protease. Publishing Authors By Initials

K Matsumoto,T Yamamoto,R Kamata,H Maeda,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: substrate specificity research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: substrate specificity research

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Pathogenesis of serratial infection: activation of the Hageman factor-prekallikrein cascade by serratial protease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 96

Page Numbers: 739-49

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Sep

YEAR: 1984

Pathogenesis of serratial infection: activation of the Hageman factor-prekallikrein cascade by serratial protease. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Pathogenesis of serratial infection: activation of the Hageman factor-prekallikrein cascade by serratial protease. Keywords Mesh Terms:

KEYWORDS: Substrate Specificity

MESH TERMS: pathogenicity

Chemical & Substance for Abstract: Pathogenesis of serratial infection: activation of the Hageman factor-prekallikrein cascade by serratial protease. Information

Substance Name: Kallikreins

Registry Number: EC 3.4.21.-

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Country: JAPAN

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MEDLINETA: J Biochem

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