Pathogenesis of osteosclerosis in autosomal dominant osteopetrosis.

Pathogenesis of osteosclerosis in autosomal dominant osteopetrosis. Research Abstract Details 

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Pathogenesis of osteosclerosis in autosomal dominant osteopetrosis. Abstract Text:

A Kovanlikaya,M L Loro,V Gilsanz,

OBJECTIVE: The purpose of this study was to determine if the generalized osteosclerosis seen on skeletal radiographs of patients with osteopetrosis is associated with an increase in bone density. SUBJECTS AND METHODS: Five children (three girls, two boys, 6-12 years old) with autosomal dominant osteopetrosis who had sustained a fracture with minimal trauma had the density and area of cortical bone at the midshaft of the femur and the amount of cancellous vertebral bone per voxel measured by quantitative CT. Values for five children with osteopetrosis were compared with measurements for two control groups of healthy subjects matched for age, sex, Tanner stage of sexual development, race, weight, and height. RESULTS: Both the area of femoral cortical bone and the amount of cancellous vertebral bone per voxel were significantly greater in the children with osteopetrosis than in the healthy children. The density of bone in the children with osteopetrosis was the same as the density in the healthy subjects. Neither sex, age, height, or weight influenced bone density, and values were similar for all 15 children. CONCLUSION: The osteosclerosis depicted on skeletal radiographs of patients with osteopetrosis results from an increase in the amount of bone, not from an increase in the percentage of mineralized bone per unit volume of tissue.

Pathogenesis of osteosclerosis in autosomal dominant osteopetrosis. Publishing Authors By Initials

A Kovanlikaya,ML Loro,V Gilsanz,

For similar tomography, x-ray computed research abstracts see: tomography, x-ray computed research

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Pathogenesis of osteosclerosis in autosomal dominant osteopetrosis. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: AJR. American journal of roentgenology

VOLUME: 168

Page Numbers: 929-32

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ISSN: 0361-803X

DAY: 15

MONTH: Apr

YEAR: 1997

Pathogenesis of osteosclerosis in autosomal dominant osteopetrosis. Information

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LANGUAGE: eng

NlmUniqueID: 7708173

Pathogenesis of osteosclerosis in autosomal dominant osteopetrosis. Keywords Mesh Terms:

KEYWORDS: Tomography, X-Ray Computed

MESH TERMS: radiography

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Grant and Affiliation Information for Pathogenesis of osteosclerosis in autosomal dominant osteopetrosis.

AFFILIATION: Department of Radiology (MS #81), Childrens Hospital Los Angeles, CA 90027, USA.

Country: UNITED STATES

AGENCY: United States NIAMS

GRANT: R01-AR4-185301A1

ACRONYM: AR

MEDLINETA: AJR Am J Roentgenol

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