Pathogenesis of Hodgkin's lymphoma.

Pathogenesis of Hodgkin's lymphoma. Research Abstract Details 

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Pathogenesis of Hodgkin's lymphoma. Abstract Text:

In Hodgkin's lymphoma (HL), the B cell origin of the tumour cells, the Hodgkin and Reed-Sternberg (HRS) cells, has been disclosed by molecular single cell analysis about 10 yr ago. This finding formed the basis for various studies aimed to better understand the pathogenesis of this peculiar malignancy and the pathophysiology of the HRS cells. Work of our groups in this regard was focussed recently on two main topics, namely the study of differential gene expression in HRS cells and the pathogenesis of composite lymphomas. Composite lymphomas are combinations of HL and B cell non-Hodgkin lymphomas, that turned out to be often clonally related. By molecular analysis of several composite lymphomas for potential transforming events, we identified examples of both shared as well as distinct transforming events. Comparing gene expression profiles of HL-derived cell lines with the corresponding profiles from other B cell lymphomas and normal B cell subsets revealed a global down-regulation of the B cell-specific gene expression signature in HRS cells. Moreover, we identifed aberrant expression and activity of multiple receptor tyrosine kinases in HRS cells of classical and to a lesser extend lymphocyte predominant HL, which appears to be a unique feature of HL, and may offer novel strategies for treatment.

Pathogenesis of Hodgkin's lymphoma. Publishing Authors By Initials

For similar cells: reed-sternberg cells research abstracts see: cells: reed-sternberg cells research

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Pathogenesis of Hodgkin's lymphoma. Journal Published:

PUBLICATION TYPE: Review

Journal: European journal of haematology. Supplementum

VOLUME:

Page Numbers: 26-33

Journal Abbreviation:

ISSN: 0902-4506

DAY: 26

MONTH: Jul

YEAR: 2005

Pathogenesis of Hodgkin's lymphoma. Information

Number of References: 59

LANGUAGE: eng

NlmUniqueID: 8703474

Pathogenesis of Hodgkin's lymphoma. Keywords Mesh Terms:

KEYWORDS: Reed-Sternberg Cells

MESH TERMS: pathology

Chemical & Substance for Abstract: Pathogenesis of Hodgkin's lymphoma. Information

Substance Name: Receptor Protein-Tyrosine Kinases

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Pathogenesis of Hodgkin's lymphoma.

AFFILIATION: Institute for Cell Biology (Tumour Research), University of Duisburg-Essen, Medical School, Essen, Germany. ralf.kuppers@uni-essen.de

Country: Denmark

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MEDLINETA: Eur J Haematol Suppl

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