Pathogenesis of erythromelalgia.

Pathogenesis of erythromelalgia. Research Abstract Details 

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Pathogenesis of erythromelalgia. Abstract Text:

A defective prostaglandin metabolism in patients with erythromelalgia may explain several of the clinical features of this condition, such as the red discoloration and burning sensations of the skin. In two patients with erythromelalgia a grossly abnormal bullous reaction to intradermally injected PGE1, PGE2, and PGF1alpha occurred, whereas a normal reaction appeared after injection of histamine, serotonin, and bradykinin. Furthermore, prostaglandin-like material was detected in increased concentration in skin perfusates from these patient. In PGE1-equivalents the concentration amounted to 2.0 and 3.2 ng/ml of the original perfusate, as compared to 0.1 ng/ml in normal skin. The capacity of synthesizing prostaglandins was increased in skin biopsy material from both patients. At least part of the therapeutic effect of aspirin in these patients may be due to the influence of this drug on prostaglandin metabolism.

Pathogenesis of erythromelalgia. Publishing Authors By Initials

For similar integumentary system: skin research abstracts see: integumentary system: skin research

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Pathogenesis of erythromelalgia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of dermatology

VOLUME: 114

Page Numbers: 112-4

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Jan

YEAR: 1978

Pathogenesis of erythromelalgia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372433

Pathogenesis of erythromelalgia. Keywords Mesh Terms:

KEYWORDS: Skin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Pathogenesis of erythromelalgia. Information

Substance Name: Prostaglandins F

Registry Number: 0

Grant and Affiliation Information for Pathogenesis of erythromelalgia.

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Country: UNITED STATES

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MEDLINETA: Arch Dermatol

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