Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease.

Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Research Abstract Details 

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Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Abstract Text:

Toshinori Yoshida,Rubin M Tuder,

Chronic obstructive pulmonary diseases (COPD), comprised of pulmonary emphysema, chronic bronchitis, and structural and inflammatory changes of small airways, is a leading cause of morbidity and mortality in the world. A better understanding of the pathobiology of COPD is critical for the developing of novel therapies, as the majority of patients with the disease have little therapeutic options at the present time. The pathobiology of COPD encompasses multiple injurious processes including inflammation (excessive or inappropriate innate and adaptive immunity), cellular apoptosis, altered cellular and molecular alveolar maintenance program, abnormal cell repair, extracellular matrix destruction (protease and anti-protease imbalance), and oxidative stress (oxidant and antioxidant imbalance). These processes are triggered by urban and rural air pollutants and active and/or passive cigarette smoke and modified by cellular senescence and infection. A series of receptor-mediated signal transduction pathways are activated by reactive oxygen species and tobacco components, resulting in impairment of a variety of cell signaling and cytokine networks, subsequently leading to chronic airway responses with mucus production, airway remodeling, and alveolar destruction. The authors provide an updated insight into the molecular and cellular pathobiology of COPD based on human and/or animal data.

Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Publishing Authors By Initials

T Yoshida,RM Tuder,

For similar plants: plant families and groups: angiosperms: solanaceae: tobacco research abstracts see: plants: plant families and groups: angiosperms: solanaceae: tobacco research

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MEDLINE DATE:

Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Physiological reviews

VOLUME: 87

Page Numbers: 1047-82

Journal Abbreviation: Physiol. Rev.

ISSN: 0031-9333

DAY: 3

MONTH: Jul

YEAR: 2007

Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 231714

Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Keywords Mesh Terms:

KEYWORDS: Tobacco

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Information

Substance Name: Smoke

Registry Number: 0

Grant and Affiliation Information for Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease.

AFFILIATION: Division of Cardiopulmonary Pathology, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01-HL-66554

ACRONYM: HL

MEDLINETA: Physiol Rev

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