Passive water-lipid Peptide translocators with conformational switches: from single-molecule probe to cellular assay.

Passive water-lipid Peptide translocators with conformational switches: from single-molecule probe to cellular assay. Research Abstract Details 

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Passive water-lipid Peptide translocators with conformational switches: from single-molecule probe to cellular assay. Abstract Text:

Ariel Fernandez,Alejandro Crespo,Axel Blau,Ariel ,Alejandro Crespo,Axel Blau,Ariel Fernández,Alejandro Crespo,Axel Blau,

Peptide design for unassisted passive water-lipid translocation remains a challenge, notwithstanding its importance for drug delivery. We introduce a design paradigm based on conformational switches operating as passive translocation vehicles. The interfacial behavior of the molecular prototype, probed in single-molecule AFM experiments, reveals a near-barrierless translocation. The associated free-energy agrees with mesoscopic measurements, and the in vitro behavior is quantitatively reproduced in cellular assays. The prototypes herald the advent of novel nanobiomaterials for passive translocation.

Passive water-lipid Peptide translocators with conformational switches: from single-molecule probe to cellular assay. Publishing Authors By Initials

A Fernandez,A Crespo,A Blau,A ,A Crespo,A Blau,A Fernández,A Crespo,A Blau,

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Passive water-lipid Peptide translocators with conformational switches: from single-molecule probe to cellular assay. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The journal of physical chemistry. B

VOLUME: 111

Page Numbers: 13987-92

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ISSN: 1520-6106

DAY: 29

MONTH: 11

YEAR: 2007

Passive water-lipid Peptide translocators with conformational switches: from single-molecule probe to cellular assay. Information

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LANGUAGE: eng

NlmUniqueID: 101157530

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Grant and Affiliation Information for Passive water-lipid Peptide translocators with conformational switches: from single-molecule probe to cellular assay.

AFFILIATION: Department of Bioengineering, Rice University, Houston, Texas 77005, and Fachbereich Physik, Technische Universität Kaiserslautern, Erwin-Schrödinger-Strasse, Gebäude 46, D-67663 Kaiserslautern, Germany.

Country: United States

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MEDLINETA: J Phys Chem B

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