Particle-induced osteolysis in three-dimensional micro-computed tomography.

Particle-induced osteolysis in three-dimensional micro-computed tomography. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Particle-induced osteolysis in three-dimensional micro-computed tomography. Abstract Text:

Christian Wedemeyer,Jie Xu,Carl Neuerburg,Stefan Landgraeber,Nasser M Malyar,Fabian von Knoch,Georg Gosheger,Marius von Knoch,Franz ,Guido Saxler,Christian Wedemeyer,Jie Xu,Carl Neuerburg,Stefan Landgraeber,Nasser M Malyar,Fabian von Knoch,Georg Gosheger,Marius von Knoch,Franz ,Guido Saxler,Christian Wedemeyer,Jie Xu,Carl Neuerburg,Stefan Landgraeber,Nasser M Malyar,Fabian von Knoch,Georg Gosheger,Marius von Knoch,Franz Löer,Guido Saxler,

Small-animal models are useful for the in vivo study of particle-induced osteolysis, the most frequent cause of aseptic loosening after total joint replacement. Microstructural changes associated with particle-induced osteolysis have been extensively explored using two-dimensional (2D) techniques. However, relatively little is known regarding the 3D dynamic microstructure of particle-induced osteolysis. Therefore, we tested micro-computed tomography (micro-CT) as a novel tool for 3D analysis of wear debris-mediated osteolysis in a small-animal model of particle-induced osteolysis. The murine calvarial model based on polyethylene particles was utilized in 14 C57BL/J6 mice randomly divided into two groups. Group 1 received sham surgery, and group 2 was treated with polyethylene particles. We performed 3D micro-CT analysis and histological assessment. Various bone morphometric parameters were assessed. Regression was used to examine the relation between the results achieved by the two methods. Micro-CT analysis provides a fully automated means to quantify bone destruction in a mouse model of particle-induced osteolysis. This method revealed that the osteolytic lesions in calvaria in the experimental group were affected irregularly compared to the rather even distribution of osteolysis in the control group. This is an observation which would have been missed if histomorphometric analysis only had been performed, leading to false assessment of the actual situation. These irregularities seen by micro-CT analysis provide new insight into individual bone changes which might otherwise be overlooked by histological analysis and can be used as baseline information on which future studies can be designed.

Particle-induced osteolysis in three-dimensional micro-computed tomography. Publishing Authors By Initials

C Wedemeyer,J Xu,C Neuerburg,S Landgraeber,NM Malyar,F von Knoch,G Gosheger,M von Knoch,F ,G Saxler,C Wedemeyer,J Xu,C Neuerburg,S Landgraeber,NM Malyar,F von Knoch,G Gosheger,M von Knoch,F ,G Saxler,C Wedemeyer,J Xu,C Neuerburg,S Landgraeber,NM Malyar,F von Knoch,G Gosheger,M von Knoch,F Löer,G Saxler,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Particle-induced osteolysis in three-dimensional micro-computed tomography. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Calcified tissue international

VOLUME: 81

Page Numbers: 394-402

Journal Abbreviation: Calcif. Tissue Int.

ISSN: 0171-967X

DAY: 21

MONTH: 10

YEAR: 2007

Particle-induced osteolysis in three-dimensional micro-computed tomography. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7905481

Particle-induced osteolysis in three-dimensional micro-computed tomography. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Particle-induced osteolysis in three-dimensional micro-computed tomography. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Particle-induced osteolysis in three-dimensional micro-computed tomography.

AFFILIATION: Department of Orthopedics, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany, christian.wedemeyer@uni-duisburg-essen.de.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Calcif Tissue Int

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Particle-induced osteolysis in three-dimensional micro-computed tomography Related Publications

• Digital templating in total hip arthroplasty with the Mayo stem.
• Jumbo cups for revision of acetabular defects after total hip arthroplasty: a retrospective review of a case series.
• Particle-induced osteolysis in three-dimensional micro-computed tomography.