Parsing the motion of single molecules: a novel algorithm for deconvoluting the dynamics of individual receptors at the cell surface.

Parsing the motion of single molecules: a novel algorithm for deconvoluting the dynamics of individual receptors at the cell surface. Research Abstract Details 

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Parsing the motion of single molecules: a novel algorithm for deconvoluting the dynamics of individual receptors at the cell surface. Abstract Text:

Indraneel Ghosh,Mary J Wirth,Indraneel Ghosh,Mary J Wirth,

To truly understand signal transduction, we will ultimately need to understand the dynamics and kinetics of individual proteins as they perform their functions in a single cell. Groundbreaking advances in single-molecule biophysics now allow us to follow the motion of many individual proteins on the cell surface with the use of fluorescent probes, such as quantum dots. However, discriminating the directed movement of single molecules from their natural Brownian motion remains a challenge. A recent paper provides a powerful statistical approach for distinguishing periods of directed motion of individual gamma-aminobutyric acid (GABA) receptors from periods during which they undergo Brownian motion. This new methodology should help single-molecule researchers determine the dynamics of individual proteins participating in signaling cascades.

Parsing the motion of single molecules: a novel algorithm for deconvoluting the dynamics of individual receptors at the cell surface. Publishing Authors By Initials

I Ghosh,MJ Wirth,I Ghosh,MJ Wirth,

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Parsing the motion of single molecules: a novel algorithm for deconvoluting the dynamics of individual receptors at the cell surface. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Science's STKE : signal transduction knowledge env

VOLUME: 2007

Page Numbers: pe28

Journal Abbreviation: Sci. STKE

ISSN: 1525-8882

DAY: 29

MONTH: 05

YEAR: 2007

Parsing the motion of single molecules: a novel algorithm for deconvoluting the dynamics of individual receptors at the cell surface. Information

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LANGUAGE: eng

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AFFILIATION: Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA. ghosh@email.arizona.edu

Country: United States

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