Paradoxical effects of two theta-defensins on HIV type 1 infection.

Paradoxical effects of two theta-defensins on HIV type 1 infection. Research Abstract Details 

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Paradoxical effects of two theta-defensins on HIV type 1 infection. Abstract Text:

Qiuwei Wang,Wei Wang,Junying Zheng,Sina Tabibian,Yiming Xie,Jun Song,Alan J Waring,Robert Chiu,Otto O Yang,Irvin S Y Chen,Robert I Lehrer,Shen Pang,

Retrocyclin-1 (RC-100) is a cyclic octadecapeptide whose primary structure is based on the sequence of an expressed human theta-defensin pseudogene. RC-111 has the same amino acid sequence as RC-100 and is also cyclic, but its residues are placed in reverse order along the peptide's backbone. We quantified the effects of RC-100 and RC-111 on HIV-1 infection using HIV clones that expressed green fluorescent protein. Whereas 0.2 microg/ml of RC-100 inhibited infection of CD4-positive cells by approximately 80%, its retro-analogue significantly enhanced infection of the cells. RC-100 and RC-111 also demonstrate their effects in HIV infection of CD4-negative cells. Whereas 40 ng/ml of RC-111 significantly enhanced infection of CD4-negative cells by HIV-1, RC-100 demonstrated significant inhibition of HIV infection with a concentration of approximately 10 microg/ml. RC-111ox, an acyclic variant of RC-111 with a beta-hairpin structure, also enhanced HIV-1 infection, but did so less effectively than cyclic RC-111. The divergent actions of RC-100 and RC-111 show that topology and polarity of theta-defensin peptides can determine their effect on HIV infection. The ability of RC-111 to enhance HIV-1 infection might prove useful in developing peptides that can enhance gene delivery by HIV-based lentiviral vectors.

Paradoxical effects of two theta-defensins on HIV type 1 infection. Publishing Authors By Initials

Q Wang,W Wang,J Zheng,S Tabibian,Y Xie,J Song,AJ Waring,R Chiu,OO Yang,IS Chen,RI Lehrer,S Pang,

For similar nervous system: neuroglia research abstracts see: nervous system: neuroglia research

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Paradoxical effects of two theta-defensins on HIV type 1 infection. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: AIDS research and human retroviruses

VOLUME: 23

Page Numbers: 508-14

Journal Abbreviation: AIDS Res. Hum. Retroviruses

ISSN: 0889-2229

DAY: 3

MONTH: Apr

YEAR: 2007

Paradoxical effects of two theta-defensins on HIV type 1 infection. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8709376

Paradoxical effects of two theta-defensins on HIV type 1 infection. Keywords Mesh Terms:

KEYWORDS: Neuroglia

MESH TERMS: virology

Chemical & Substance for Abstract: Paradoxical effects of two theta-defensins on HIV type 1 infection. Information

Substance Name: theta-defensin

Registry Number: 0

Grant and Affiliation Information for Paradoxical effects of two theta-defensins on HIV type 1 infection.

AFFILIATION: UCLA School of Dentistry, and Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA 90095, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI 056921

ACRONYM: AI

MEDLINETA: AIDS Res Hum Retroviruses

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